Journal of Ardabil University of Medical Sciences, 2015 Backgrounds & objectives: In addition to their genomic actions, thyroid hormones (THs) can modulate the immune responses through cell surface receptors. One of these is the antiviral effect of THs. Methimazole, as an anti-thyroid compound, is widely used
Hadi Feizi +3 more
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Cholestasis and Acute Cholecystitis in Hyperthyroidism Treated With Methimazole
International Journal of Gerontology, 2009 Hepatic dysfunction and jaundice are usually present in patients with hyperthyroidism. It may be the clinical manifestation of the disease or the adverse effect of antithyroid therapy.
Wei-Che Chen +3 more
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How to discontinue potassium iodide in combined therapy with methimazole for initial treatment of Graves’ disease [PDF]
Endocrine JournalThe combination of methimazole (MMI) and potassium iodide (KI) is often used to improve the thyroid function more quickly in the initial medical treatment of Graves’ disease when the levels of free T4 are ≥5.0 ng/dL.
Tsukasa Murakami +4 more
doaj +2 more sources
Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine [PDF]
Advanced Pharmaceutical Bulletin, 2014 Purpose: Methimazole is the most convenient drug used in the management of hyperthyroid patients. However, associated with its clinical use is hepatotoxicity as a life threatening adverse effect.
Reza Heidari +3 more
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Cytoprotective Effects of Organosulfur Compounds against Methimazole-Induced Toxicity in Isolated Rat Hepatocytes [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Methimazole is a drug widely used in hyperthyroidism. However, life-threatening hepatotoxicity has been associated with its clinical use. No protective agent has been found to be effective against methimazole-induced hepatotoxicity yet.
Mohammad Ali Eghba +2 more
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Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves’ Disease [PDF]
Endocrinology and Metabolism, 2022 Background An excess of thyroid hormones in Graves’ disease (GD) has profound effects on systemic energy metabolism that are currently partially understood.
Ho Yeop Lee +9 more
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Colorimetric Determination of Thioamide Drugs Based on the Surface Plasmon Resonance Band of Colloidal Silver Nanoparticles [PDF]
شیمی کاربردی روز, 2013 In this article, we report a new method for the determination of two thioamide drugs, propylthiouracil (PTU) and methimazole (MMZ), with unmodified silver nanoparticles (AgNPs).
Jafar Abolhasani +3 more
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Frontiers in Endocrinology, 2021 BackgroundHyperthyroidism is related to vascular atherosclerosis. Propylthiouracil (PTU) and methimazole, other than their antithyroid effects, may have different mechanisms in preventing atherogenesis in Graves’ disease.ObjectiveThis study aimed to ...
Wismandari Wisnu +9 more
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Efficacy and adverse events related to the initial dose of methimazole in children and adolescents with Graves’ disease [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Purpose The first-line antithyroid drug for children and adolescents with Graves’ disease (GD) is methimazole (MMI). This study evaluated the relationship between the initial MMI dose and the clinical course of GD after treatment.
Hyun Gyung Lee +2 more
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Preparation of Au@Ir/C as sensor for Methimazole Detection
International Journal of Electrochemical Science, 2018 Au@Ir/C nanocomposite as an electroactive material for methimazole detection has been synthesized via polyol reduction method. Physical tests demonstrate that ultrafine nanoparticles of Au@Ir composite (2-4 nm) are evenly dispersed on carbon.
Si Chen +8 more
doaj +1 more source