Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents [PDF]
Molecules, 2018 Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (
Samir M. Awad +4 more
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Factors affecting drug-induced liver injury: antithyroid drugs as instances [PDF]
Clinical and Molecular Hepatology, 2014 Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications.
Reza Heidari +3 more
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An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury [PDF]
Advanced Pharmaceutical Bulletin, 2015 Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied.
Reza Heidari +4 more
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Drug cross-reactivity between methimazole and propylthiouracil causing recurrent pancreatitis in thyroid storm [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsDrug-induced pancreatitis represents 1.1% of acute pancreatitis cases. To date, eight cases of antithyroid drug (ATD)-induced pancreatitis have been reported, including seven associated with methimazole (MMI) and one with carbimazole; however, no cases ...
Yuriko Yamazaki +8 more
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Predictive factors for remission in pediatric Graves’ disease treated with antithyroid drugs: a retrospective study [PDF]
Archives of Endocrinology and MetabolismObjective: Pediatric Graves’ disease (PGD) is a rare autoimmune disorder. Predictors of remission after antithyroid drug (ATD) therapy have been described, but their applicability in pediatric populations remains inconsistent.
Ana João Fernandes +7 more
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Case Report: Hyperthyroidism induced liver failure with Wolff–Parkinson–White syndrome [PDF]
Frontiers in MedicineLiver failure is a critical condition secondary to not only hepatopathy but also extrahepatic etiologies. This article presents a unique case of hyperthyroidism-induced liver failure complicated with Wolff–Parkinson–White syndrome and pneumonia.
Yifan Ke, Yuankai Wu, Yutian Chong
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Prevalence, Treatment Status, and Comorbidities of Hyperthyroidism in Korea from 2003 to 2018: A Nationwide Population Study [PDF]
Endocrinology and Metabolism, 2023 Background This study aimed to investigate the changes of incidence and treatment of choice for hyperthyroidism from 2003 to 2018 and explore the treatment-related complications and concomitant comorbidities in South Korea using data from the National ...
Hwa Young Ahn +6 more
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Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study [PDF]
Endocrinology and Metabolism, 2022 Background Hyperthyroidism is associated with an increased glomerular filtration rate (GFR) in the hyperdynamic state, which is reversible after restoring euthyroidism.
Yoon Young Cho +10 more
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Prediction of the recurrence risk of Graves' disease after antithyroid drug therapy
Environmental Disease, 2023 Objective: This study aimed at observing the prognostic factors for Graves' disease (GD) recurrence after treatment with antithyroid drugs. Patients and Methods: Clinical data for 247 patients with primary GD hyperthyroidism diagnosed in the ...
Qiang Zhang, Ying Fu
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Antithyroid arthritis syndrome caused by methimazole in a patient with Graves’ disease
Endocrinology, Diabetes & Metabolism Case Reports, 2023 This is a report on antithyroid arthritis syndrome (AAS) which is a rare adverse effect of antithyroid agents. AAS presents with severe symptoms including myalgia, arthralgia, arthritis, fever, and skin eruption due to the use of antithyroid agents.
Muneo Kawasumi +3 more
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