Results 41 to 50 of about 3,970 (174)

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Carbimazole induced agranulocytosis with life-threatening complications, tremendous response with granulocyte-colony stimulating factor

Medical Journal of Dr. D.Y. Patil University, 2016
Agranulocytosis is a rare complication of drug carbimazole (0.23%). We are accounting to present a very interesting and rare case of agranulocytosis and neutropenic sepsis secondary to carbimazole that have tremendous response with recombinant human ...
Seema Mahant, Upasana Shobhane, P D Mahant   +2 more
doaj   +1 more source

Claustrum Sign in Hashimoto Encephalopathy Presenting With New Onset Refractory Status Epilepticus (NORSE): First Report of a Rare Phenotype

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT The presence of the bilateral claustrum sign in new‐onset refractory status epilepticus (NORSE) should prompt consideration of Hashimoto's encephalopathy, even without thyroid dysfunction. Early recognition and corticosteroid therapy can be lifesaving, emphasizing an autoimmune‐inflammatory mechanism underlying this rare presentation.
Zahra‐Sadat Mirian, Mohammad Amin Najafi, Alireza Anjam Majoumerd, Ali Khoshnevisan, Mohammad Reza Najafi   +4 more
wiley   +1 more source

Withania somnifera Root Extract Ameliorates PTU‐Induced Hypothyroidism by Regulating Hormone Levels and Gene Expression in Rats

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Graphical abstract for the integrated in silico and in vivo approach demonstrating the Methanolic extract of Withania somnifera root ameliorated PTU‐induced hypothyroidism through the regulation of thyroid hormone levels, gene expression, and thyroid histopathology.
Md. Saud Hossain, Md. Shah Poran Shuvo, M. Maruf Hasan Talukder, Shahidullah, Sumaia Jannat, S. M. Riaduzzaman Niaz, Md Sohel, Md. Khairul Islam   +7 more
wiley   +1 more source

Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Cleisla Souza Oliveira, Maria Clara Pascoal Santos Alvarez, Natália Panhoca Rodrigues, Jorge Lopez‐Tello, Amanda N. Sferruzzi‐Perri, Rogéria Serakides, Juneo Freitas Silva   +9 more
wiley   +1 more source

Hashimoto's encephalopathy (a brief review of literature and a clinical case)

Неврология, нейропсихиатрия, психосоматика, 2019
Hashimoto's encephalopathy (HE) is a steroid-responsive encephalopathy associated with autoimmune thyroiditis; it is based on the inflammatory brain process associated with a cross-reaction to anti-thyroid autoantibodies.
М. A. Kutlubaev, O. V. Gekhtman, E. N. Zakirova   +2 more
doaj   +1 more source

Sequential Amiodarone‐Induced Thyroid Dysfunction: From Myxedema Coma to Late‐Onset Type 1 Thyrotoxicosis After Drug Withdrawal

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Amiodarone therapy may induce thyroid dysfunction in approximately 20% of patients, either amiodarone‐induced hypothyroidism (AIH) or thyrotoxicosis (AIT). Both situations may occur at any time during treatment or even months to years after drug withdrawal due to tissue storage with slow systemic release.
Daniela M. Soares, Lia Ferreira
wiley   +1 more source

Drug-Induced Liver Injury: A Unique Presentation of Single-Dose Administration of Propylthiouracil

Journal of Investigative Medicine High Impact Case Reports, 2020
Antithyroid drug-induced severe liver injury is an uncommon but serious complication. We hereby delineate the case of a 38-year-old female who presented to the emergency department for an impending thyroid storm.
Simcha Weissman DO, Nishan G. Rajaratnam MD, Nabeel Qureshi MD, Faisal Inayat MBBS, Sameh Elias MD, FACP   +4 more
doaj   +1 more source

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

ChemistryEurope, Volume 4, Issue 2, February 2026.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña, Zeyu Feng, David Herrero, Martin Simon, Christopher Golz, Manuel Alcarazo   +5 more
wiley   +1 more source

Current and emerging treatment options for Graves’ hyperthyroidism

Therapeutics and Clinical Risk Management, 2009
Prakash Abraham1, Shamasunder Acharya21Department of Endocrinology, Aberdeen Royal Infirmary, Aberdeen, UK; 2Department of Endocrinology, John Hunter Hospital, New Lambton NSW, AustraliaAbstract: Radioiodine, antithyroid drugs and surgery have been well ...
Prakash Abraham, Shamasunder Acharya
doaj