Results 51 to 60 of about 3,970 (174)
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
Acute Medicine &Surgery, Volume 13, Issue 1, January/December 2026.In a Japanese emergency department, 7.9% of overdose cases involved nonmedical use of prescription drugs, primarily obtained from family or friends. NMUPD cases more often featured alcohol coingestion and limited psychiatric engagement and involved multiple commonly prescribed psychotropic drug classes rather than a single class.
Nobuki Shioya +9 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Sinomenine, derived from Sinomenium acutum, is widely used in inflammatory diseases. However, its risk of inducing agranulocytosis is not widely appreciated. We report a life‐threatening case in a 40‐year‐old woman with chronic kidney disease (CKD; baseline estimated glomerular filtration rate [eGFR] as low as 36 mL/min/1.73 m2) who developed ...
Ping Xin, Ruoyan Liu, Yu Zhang, Bin Fu
wiley +1 more source
Lymphocyte profile in patients with Grave’s disease depending on the degree of its compensation
Mìžnarodnij Endokrinologìčnij Žurnal, 2018 Background. In Ukraine today, the main method for the treatment of Grave’s disease (GD) is the administration of antithyroid drugs in order to achieve euthyroidism.
O.A. Goncharova
doaj +1 more source
Thyrotoxic periodic paralysis: Report of two cases and a short review of the literature
Endocrinology Research and Practice, 2007 Thyrotoxic periodic paralysis (TPP) is a fatal complication of hyperthyroidism which is characterized by muscle weakness and hypokalemia. In the literature, Asian populations are reported to have a vulnerability to TPP.
Filiz Ekşi Haydardedeoğlu +5 more
doaj +2 more sources
Cadernos de Saúde Pública, 2002 Occupational exposure to some pesticides, and particularly DBCP and chlordecone, may adversely affect male fertility. However, apart from the therapeutic use of diethylstilbestrol, the threat to human reproduction posed by "endocrine disrupting ...
Pierluigi Cocco
doaj +1 more source
CompoundsThe thionamide antithyroid agents were discovered largely through observations carried out by various researchers in the 1940s that found that sulfhydryl-containing substances were goitrogenic in animals. Prof. Edwin B.
Petja Emilova Marinova +1 more
doaj +1 more source
Hyperthyroidism in the pregnant woman: Maternal and fetal aspects
Journal of Clinical & Translational Endocrinology, 2019 Hyperthyroidism during pregnancy is uncommon. Nonetheless, prompt identification and adequate management of hyperthyroidism in a pregnant woman is essential, because uncontrolled thyrotoxicosis significantly increases the risk of maternal and fetal ...
Mariacarla Moleti +4 more
doaj +1 more source
Frontiers in ImmunologySteroid Responsive Encephalopathy Associated with Autoimmune Thyroiditis (SREAT), or Hashimoto’s encephalopathy, is a rare autoimmune neurological disorder linked to elevated antithyroid antibodies and presenting various neurological symptoms.
Palash Kotak +4 more
doaj +1 more source
Methimazole-Induced Leukocytoclastic Vasculitis: A Case Report
Case Reports in Dermatology, 2019 Major identifiable causes of leukocytoclastic vasculitis include certain infections and medications. Amongst antithyroid drugs, methimazole (MMI) is rarely implicated as a culprit drug.
Weeratian Tawanwongsri +1 more
doaj +1 more source