Results 51 to 60 of about 3,759,221 (188)

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Drug-Induced Liver Injury: A Unique Presentation of Single-Dose Administration of Propylthiouracil

Journal of Investigative Medicine High Impact Case Reports, 2020
Antithyroid drug-induced severe liver injury is an uncommon but serious complication. We hereby delineate the case of a 38-year-old female who presented to the emergency department for an impending thyroid storm.
Simcha Weissman DO, Nishan G. Rajaratnam MD, Nabeel Qureshi MD, Faisal Inayat MBBS, Sameh Elias MD, FACP   +4 more
doaj   +1 more source

Claustrum Sign in Hashimoto Encephalopathy Presenting With New Onset Refractory Status Epilepticus (NORSE): First Report of a Rare Phenotype

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT The presence of the bilateral claustrum sign in new‐onset refractory status epilepticus (NORSE) should prompt consideration of Hashimoto's encephalopathy, even without thyroid dysfunction. Early recognition and corticosteroid therapy can be lifesaving, emphasizing an autoimmune‐inflammatory mechanism underlying this rare presentation.
Zahra‐Sadat Mirian, Mohammad Amin Najafi, Alireza Anjam Majoumerd, Ali Khoshnevisan, Mohammad Reza Najafi   +4 more
wiley   +1 more source

Withania somnifera Root Extract Ameliorates PTU‐Induced Hypothyroidism by Regulating Hormone Levels and Gene Expression in Rats

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Graphical abstract for the integrated in silico and in vivo approach demonstrating the Methanolic extract of Withania somnifera root ameliorated PTU‐induced hypothyroidism through the regulation of thyroid hormone levels, gene expression, and thyroid histopathology.
Md. Saud Hossain, Md. Shah Poran Shuvo, M. Maruf Hasan Talukder, Shahidullah, Sumaia Jannat, S. M. Riaduzzaman Niaz, Md Sohel, Md. Khairul Islam   +7 more
wiley   +1 more source

Current and emerging treatment options for Graves’ hyperthyroidism

Therapeutics and Clinical Risk Management, 2009
Prakash Abraham1, Shamasunder Acharya21Department of Endocrinology, Aberdeen Royal Infirmary, Aberdeen, UK; 2Department of Endocrinology, John Hunter Hospital, New Lambton NSW, AustraliaAbstract: Radioiodine, antithyroid drugs and surgery have been well ...
Prakash Abraham, Shamasunder Acharya
doaj  

Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Cleisla Souza Oliveira, Maria Clara Pascoal Santos Alvarez, Natália Panhoca Rodrigues, Jorge Lopez‐Tello, Amanda N. Sferruzzi‐Perri, Rogéria Serakides, Juneo Freitas Silva   +9 more
wiley   +1 more source

Sequential Amiodarone‐Induced Thyroid Dysfunction: From Myxedema Coma to Late‐Onset Type 1 Thyrotoxicosis After Drug Withdrawal

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Amiodarone therapy may induce thyroid dysfunction in approximately 20% of patients, either amiodarone‐induced hypothyroidism (AIH) or thyrotoxicosis (AIT). Both situations may occur at any time during treatment or even months to years after drug withdrawal due to tissue storage with slow systemic release.
Daniela M. Soares, Lia Ferreira
wiley   +1 more source

Lymphocyte profile in patients with Grave’s disease depending on the degree of its compensation

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. In Ukraine today, the main method for the treatment of Grave’s disease (GD) is the administration of antithyroid drugs in order to achieve euthyroidism.
O.A. Goncharova
doaj   +1 more source

Thyrotoxic periodic paralysis: Report of two cases and a short review of the literature

Endocrinology Research and Practice, 2007
Thyrotoxic periodic paralysis (TPP) is a fatal complication of hyperthyroidism which is characterized by muscle weakness and hypokalemia. In the literature, Asian populations are reported to have a vulnerability to TPP.
Filiz Ekşi Haydardedeoğlu, Okan Bakıner, Melek Eda Ertörer, Emre Bozkırlı, Neslihan Başçıl Tütüncü, Nilgün Güvener Demirağ   +5 more
doaj   +2 more sources

Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Compounds
The thionamide antithyroid agents were discovered largely through observations carried out by various researchers in the 1940s that found that sulfhydryl-containing substances were goitrogenic in animals. Prof. Edwin B.
Petja Emilova Marinova, Kristina Dimova Tamahkyarova   +1 more
doaj   +1 more source