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Interaction Of Propylthiouracil With Model Systems Generating A Superoxide Radical [PDF]
Journal of Biomedical & Clinical Research, 2014 Propylthiouracil is used against Grave's Disease and for developing animal models of hypothyroidism. Apart from depressed metabolism, free radical-induced tissue damage has been registered as an effect from this drug.
Maria Valcheva-Traykova +2 more
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Can propylthiouracil induce autoimmune-related immunotoxicity? [PDF]
Vojnosanitetski Pregled, 2022 Introduction. The use of propylthiouracil can be associated with mild adverse reactions, but severe complications such as agranulocytosis and vasculitis can also be seen.
Bajkin Ivana +4 more
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Effect of aqueous rosemary extract on some sexual hormones in male rats with high thyroxine level [PDF]
Iraqi Journal of Veterinary Sciences, 2021 The main purpose of this research is to evaluate the high level of thyroxine affects on each of the luteinizing hormone (LH), testosterone, follicle-stimulating hormone (FSH) of rats and to estimate the potential effect of the administration of aqueous ...
Fouad Z. Hamza +2 more
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PLoS ONE, 2022 Background Hyperthyroidism affects about 0.2%-2.7% of all pregnancies, and is generally treated with propylthiouracil (PTU). However, previous studies about the effects of propylthiouracil on maternal or foetal are contentious.
Yiqun Miao +6 more
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Does Withania somnifera mitigate the structural alterations of the rat brain associated with propylthiouracil? [PDF]
Iraqi Journal of Veterinary Sciences, 2022 The repercussion of propylthiouracil (PTU) use postnatally on brain histology have not yet been intensely scrutinized. To examine whether Withania somnifera mitigate the structural effects of propylthiouracil on rat brain, rats were distributed into ...
Luma I. Khalel, Osamah M. Al-Iraqi
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Analysis of pharmacotherapeutic approach in patients with hyperthyroidism [PDF]
Medicinski Podmladak, 2022 Introduction: Hyperthyroidism represents a condition that occurs due to increased synthesis of thyroid hormones (T3, T4). In 90% of all cases it is caused by: Graves' disease, toxic multinodular goiter and toxic adenoma.
Đokić Ana +3 more
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DRESS/DiHS syndrome induced by Propylthiouracil: a case report
BMC Endocrine Disorders, 2023 Background Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as Drug-induced hypersensitivity syndrome (DiHS), is a severe adverse drug reaction. Propylthiouracil, a member of thiouracils group, is widely used in medical treatment
Qiong Shen +6 more
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Clinical pharmacology of thyroid and antithyroid drugs [PDF]
Arhiv za farmaciju, 2022 Autoimmune diseases accompanied by the development of hypothyroidism (Hashimoto's thyroiditis) and hyperthyroidism (Graves' disease) are one of the most common disorders of the thyroid gland.
Stepanović-Petrović Radica +1 more
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Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals
Pharmaceuticals, 2023 Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide
Francisco Javier Acebedo-Martínez +7 more
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Pharmaceuticals, 2021 Propylthiouracil (PTU) is commonly prescribed for the management of hyperthyroidism and thyrotoxicosis. Although the exact mechanism of action is not fully understood, PTU is associated with hepatoxicity in pediatric population.
Min Li +7 more
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