Acute Liver Failure Associated with Propylthiouracil in a Pregnant 26-Year-Old Woman
Case Reports in Gastroenterology, 2013 It seems appropriate to use propylthiouracil to treat maternal hyperthyroidism during the first trimester of pregnancy. We present the case of a 26-year-old woman with acute liver failure associated with propylthiouracil during the first trimester of ...
Tatsuo Miyamura +9 more
doaj +2 more sources
Congenital Bands with Intestinal Malrotation after Propylthiouracil Exposure in Early Pregnancy [PDF]
Case Reports in Endocrinology, 2015 Exposure to propylthiouracil in early pregnancy may be associated with an increased risk of birth defects. But the spectrum of associated congenital anomalies is not yet well defined.
Alexander A. Leung +4 more
doaj +2 more sources
A case of propylthiouracil induced antineutrophil cytoplasmic antibody associated vasculopathy
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Nikhil Dwivedi +2 more
wiley +2 more sources
Establishment of a mouse model of propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. [PDF]
Animal Model Exp MedThis graphical abstract summarizes our study in which we established a novel murine model of antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis. Neutrophil recruitment was induced using thioglycolate, followed by timed administration of propylthiouracil and phorbol 12‐myristate 13‐acetate to generate DNase I‐resistant neutrophil ...
Masuda S +9 more
europepmc +2 more sources
Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals
Pharmaceuticals, 2023 Pharmaceutical multicomponent solids have proved to efficiently modulate the physicochemical properties of active pharmaceutical ingredients. In this context, polyphenols are interesting coformers for designing pharmaceutical cocrystals due to their wide
Francisco Javier Acebedo-Martínez +7 more
doaj +1 more source
Pharmaceuticals, 2021 Propylthiouracil (PTU) is commonly prescribed for the management of hyperthyroidism and thyrotoxicosis. Although the exact mechanism of action is not fully understood, PTU is associated with hepatoxicity in pediatric population.
Min Li +7 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Toxicology Reports, 2020 Hypothyroidism is the most frequent consequence of the interaction of a large variety of drugs, environmental pollutants and industrial chemicals with the thyroid gland. It is associated with diminished endocrine function which may lead to hyperlipidemia,
Sneha Singh +3 more
doaj +1 more source
Teratogenic effects of Propylthiouracil on Swiss albino mice fetuses – A gross study
Asian Journal of Medical Sciences, 2022 Background: Propylthiouracil is an antithyroid drug used to treat hyperthyroidism in pregnancy, as euthyroid state is necessary for optimal pregnancy outcome.
Samta Tiwari +2 more
doaj +1 more source
Risk of congenital anomalies associated with antithyroid treatment during pregnancy: a meta-analysis
Clinics, 2015 To evaluate the association of either propylthiouracil or methimazole treatment for hyperthyroidism during pregnancy with congenital malformations, relevant studies were identified by searching Medline, PubMed, the Cochrane Library and EMBASE.
Xiang Li +3 more
doaj +1 more source