Results 61 to 70 of about 6,475 (230)
TRH: Pathophysiologic and clinical implications [PDF]
, 1985 Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin.
A. Enjalbert +82 more
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ChemistryEurope, Volume 4, Issue 2, February 2026.The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña +5 more
wiley +1 more source
Henoch–Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis
Case Reports in Endocrinology, 2021 Graves’ disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema.
Mojgan Sanjari +2 more
doaj +1 more source
Mechanism of the Inhibition of Enzymatic Halogenation by Antithyroid Agents
Journal of Biological Chemistry, 1966 Abstract Antithyroid agents of the thiourea type (thiourea, thiouracil, and 5-vinyl-2-oxazolidinethione) inhibit the enzymatic halogenation reactions catalyzed by chloroperoxidase. These compounds are competitive with the halogen acceptor molecule and serve as substrates for chloroperoxidase. These antithyroid agents are oxidized by chloroperoxidase in
D R, Morris, L P, Hager
openaire +2 more sources
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
Acute Medicine &Surgery, Volume 13, Issue 1, January/December 2026.In a Japanese emergency department, 7.9% of overdose cases involved nonmedical use of prescription drugs, primarily obtained from family or friends. NMUPD cases more often featured alcohol coingestion and limited psychiatric engagement and involved multiple commonly prescribed psychotropic drug classes rather than a single class.
Nobuki Shioya +9 more
wiley +1 more source
Does choice of therapy save costs and improve outcomes in hyperthyroid patients [PDF]
, 2008 OBJECTIVE: To compare cost of treating hyperthyroidism with antithyroid medications (ATD) versus radioactive iodine (RAI). As secondary outcome we also analyzed data in terms of remission rates.
Akhter, J. +4 more
core +1 more source
Evaluation of a pharmacist-led medication assessment used to identify prevalence of and associations with polypharmacy and potentially inappropriate medication use among ambulatory senior adults with cancer. [PDF]
, 2015 PURPOSE: The use of multiple and/or inappropriate medications in seniors is a significant public health problem, and cancer treatment escalates its prevalence and complexity.
Andrel-Sendecki, Jocelyn +4 more
core +2 more sources
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Sinomenine, derived from Sinomenium acutum, is widely used in inflammatory diseases. However, its risk of inducing agranulocytosis is not widely appreciated. We report a life‐threatening case in a 40‐year‐old woman with chronic kidney disease (CKD; baseline estimated glomerular filtration rate [eGFR] as low as 36 mL/min/1.73 m2) who developed ...
Ping Xin, Ruoyan Liu, Yu Zhang, Bin Fu
wiley +1 more source
Thyroid disease : diagnosis and management of Hyperthyroidism [PDF]
, 2005 This short review article aims to provide updated information on the diagnosis and management of hyperthymidism.
Caruana, Noel
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