Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents [PDF]
Molecules, 2018 Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-n-propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (
Samir M. Awad +4 more
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Drug cross-reactivity between methimazole and propylthiouracil causing recurrent pancreatitis in thyroid storm [PDF]
Endocrinology, Diabetes & Metabolism Case ReportsDrug-induced pancreatitis represents 1.1% of acute pancreatitis cases. To date, eight cases of antithyroid drug (ATD)-induced pancreatitis have been reported, including seven associated with methimazole (MMI) and one with carbimazole; however, no cases ...
Yuriko Yamazaki +8 more
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Case Report: Hyperthyroidism induced liver failure with Wolff–Parkinson–White syndrome [PDF]
Frontiers in MedicineLiver failure is a critical condition secondary to not only hepatopathy but also extrahepatic etiologies. This article presents a unique case of hyperthyroidism-induced liver failure complicated with Wolff–Parkinson–White syndrome and pneumonia.
Yifan Ke, Yuankai Wu, Yutian Chong
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Prevalence, Treatment Status, and Comorbidities of Hyperthyroidism in Korea from 2003 to 2018: A Nationwide Population Study [PDF]
Endocrinology and Metabolism, 2023 Background This study aimed to investigate the changes of incidence and treatment of choice for hyperthyroidism from 2003 to 2018 and explore the treatment-related complications and concomitant comorbidities in South Korea using data from the National ...
Hwa Young Ahn +6 more
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Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study [PDF]
Endocrinology and Metabolism, 2022 Background Hyperthyroidism is associated with an increased glomerular filtration rate (GFR) in the hyperdynamic state, which is reversible after restoring euthyroidism.
Yoon Young Cho +10 more
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Prediction of the recurrence risk of Graves' disease after antithyroid drug therapy
Environmental Disease, 2023 Objective: This study aimed at observing the prognostic factors for Graves' disease (GD) recurrence after treatment with antithyroid drugs. Patients and Methods: Clinical data for 247 patients with primary GD hyperthyroidism diagnosed in the ...
Qiang Zhang, Ying Fu
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ABC approach for the management of adults with hyperthyroidism: A practical strategy in primary care [PDF]
Malaysian Family Physician, 2023 Hyperthyroidism is commonly seen in primary care settings. However, the management of hyperthyroidism might be unclear to primary care doctors. Various guidelines have been published to assist clinicians in the management of thyroid disorders at various ...
Jazlan Jamaluddin +6 more
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Antithyroid Drug Treatment in Graves’ Disease [PDF]
Endocrinology and Metabolism, 2021 Graves’ disease is associated with thyrotropin (TSH) receptor stimulating antibody, for which there is no therapeutic agent. This disease is currently treated through inhibition of thyroid hormone synthesis or destruction of the thyroid gland. Recurrence
Jae Hoon Chung
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Factors affecting drug-induced liver injury: antithyroid drugs as instances [PDF]
Clinical and Molecular Hepatology, 2014 Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications.
Reza Heidari +3 more
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An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury [PDF]
Advanced Pharmaceutical Bulletin, 2015 Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied.
Reza Heidari +4 more
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