Results 91 to 100 of about 9,836 (223)

Biopharmaceuticals for Cancer Treatment: An Update

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath, Yousuf Alam, Afsana Mustak Mim, Maksuda Akter, Mohammad Abbas Gani, Khondaker Muhammad Khairul Alam, Md. Nur Alam   +6 more
wiley   +1 more source

Contact-dependent growth inhibition systems in Acinetobacter [PDF]

, 2019
In bacterial contact-dependent growth inhibition (CDI) systems, CdiA proteins are exported to the outer membrane by cognate CdiB proteins. CdiA binds to receptors on susceptible bacteria and subsequently delivers its C-terminal toxin domain (CdiA-CT ...
De Gregorio, Eliana, Di Nocera, Pier Paolo, Zarrilli, Raffaele   +2 more
core   +2 more sources

Insecticide@Silica Nanocontainers with High Cypermethrin Load and Improved Photostability

ChemNanoMat, Volume 12, Issue 4, April 2026.
Cypermethrin@Octylsilicate core@shell nanocontainers (total diameter: 34 nm, diameter of cypermethrin core: 15 nm) exhibit high colloidal stability in water and high photochemical stability of the insecticide, allowing to reduce reapplication cycles and, thus, time and costs of insecticide application.
Mark Rutschmann, Jasmin Mokinski, Claus Feldmann   +2 more
wiley   +1 more source

Inventory Management Performance for Lifesaving Maternal and Child Health Medicines in Amhara Regional State, Ethiopia: A Facility‐Based Cross‐Sectional Mixed Method Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Maternal mortality is a major public health issue in Ethiopia, with 412 deaths per 100,000 live births. Pregnancy‐related causes make up 25% of female deaths, highlighting the crisis's seriousness. Improving inventory management could enhance health system performance.
Ayalew Sirbemo Degebo, Gizachew Tilahun
wiley   +1 more source

Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters

mLife, Volume 5, Issue 2, Page 180-198, April 2026.
Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei, Yawen Cai, Jianfeng Huang, Kedong Zhao, Zuqin Zhang, Dandan Yu, Shiyan Lu, Zeying Lai, Thomas K. Wood, Xinmiao Fu   +9 more
wiley   +1 more source

Toxin-Antitoxin Modules Are Pliable Switches Activated by Multiple Protease Pathways

Toxins, 2016
Toxin-antitoxin (TA) modules are bacterial regulatory switches that facilitate conflicting outcomes for cells by promoting a pro-survival phenotypic adaptation and/or by directly mediating cell death, all through the toxin activity upon degradation of ...
Meenakumari Muthuramalingam, John C. White, Christina R. Bourne   +2 more
doaj   +1 more source

Recent advances in noncanonical inhibition mechanisms of anti‐CRISPR proteins

mLife, Volume 5, Issue 2, Page 133-147, April 2026.
Abstract The CRISPR‐Cas system constitutes an adaptive immune mechanism in prokaryotes that defends against mobile genetic elements. Within the perpetual co‐evolutionary arms race between bacteria and their viral predators, bacteriophages encode anti‐CRISPR (Acr) proteins that use sophisticated molecular strategies to sabotage CRISPR‐Cas function ...
Lingguang Yang, Rongjun Luo, Wei Zhou, Peipei Yin, Yue Feng, Yi Zhang   +5 more
wiley   +1 more source

Pantothenate kinase: A promising therapeutic target against pathogenic Clostridium species

Heliyon
Current treatment of clostridial infections includes broad-spectrum antibiotics and antitoxins, yet antitoxins are ineffective against all Clostridiumspecies.
Soharth Hasnat, M. Nazmul Hoque, M Murshida Mahbub, Tahsin Islam Sakif, A.D.A. Shahinuzzaman, Tofazzal Islam   +5 more
doaj   +1 more source

Quality of horse F(ab’)2 antitoxins and anti-rabies immunoglobulins: protein content and anticomplementary activity

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background Among other applications, immunotherapy is used for the post-exposure treatment and/or prophylaxis of important infectious diseases, such as botulism, diphtheria, tetanus and rabies.
Carla Cristina Squaiella-Baptistão, Fábio Carlos Magnoli, José Roberto Marcelino, Osvaldo Augusto Sant’Anna, Denise V. Tambourgi   +4 more
doaj   +1 more source

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

Microbiology and Immunology, Volume 70, Issue 4, Page 206-213, April 2026.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa, Tatsuki Miyamoto, Rino Isshiki, Tomoyoshi Kaneko, Kenichi Takasugi, Naohiro Noda, Satoshi Tsuneda   +6 more
wiley   +1 more source