Results 71 to 80 of about 1,053 (146)

From mouth to brain: Linking periodontal and peri‐implant dysbiosis to systemic inflammation and neuropathology

Periodontology 2000, EarlyView.
Abstract Background/Aim Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. Materials and Methods A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was ...
Emilio A. Cafferata, Frank Schwarz, Jaime Díaz‐Zúñiga, Alpdogan Kantarci   +3 more
wiley   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil

Brazilian Journal of Medical and Biological Research
Tetanus and diphtheria vaccines are of special concern in adolescents because boosters are necessary for adequate maintenance of protection and are often omitted.
M.I.S Dinelli, M Fisberg, M.I de Moraes-Pinto   +2 more
doaj   +1 more source

Intrinsic Disorder as a New Frontier in Antimicrobial Resistance and Bacterial Fitness

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The works examines the link between intrinsic disorder in bacterial protein structure, and bacterial function, and antimicrobial resistance. It highlights how flexible, disordered proteins support secretion, stress responses, desiccation protection, and virulence, while also suggesting that these adaptable regions may provide novel targets for ...
Jack O' Callaghan, Michael P. Ryan, Sarah Hudson, Damien Thompson   +3 more
wiley   +1 more source

Bioinformatic exploration reveals features of tenpIN family of type III toxin-antitoxin systems in bacteria and viruses

Scientific Reports
Toxin-antitoxin (TA) systems in bacteria consist of two genes: one encoding a toxin that inhibits essential cellular processes and the other encoding an antitoxin that neutralizes the toxin under homeostatic conditions.
Kavyashree Nadig, Sankaran Sandhya, Mahavir Singh   +2 more
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source

Asking the 5 W's for designing next‐generation bioprocessing

AIChE Journal, Volume 72, Issue 9, September 2026.
Abstract Biotechnology is expanding beyond traditional, centralized fermentation and toward next‐generation bioprocessing paradigms that emphasize flexible deployment outside the laboratory with application‐specific performance. However, many bioprocesses fail to translate beyond proof‐of‐concept into industrially viable systems because early design ...
Sangdo Yook, Karoline Maria Vieira Nogueira, Raj Sukumar, Jenna Miller, Hal S. Alper   +4 more
wiley   +1 more source

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

Biology Direct, 2009
Background The prokaryotic toxin-antitoxin systems (TAS, also referred to as TA loci) are widespread, mobile two-gene modules that can be viewed as selfish genetic elements because they evolved mechanisms to become addictive for replicons and cells in ...
Makarova Kira S, Wolf Yuri I, Koonin Eugene V   +2 more
doaj   +1 more source

Antioxidant Chemistry of Phenolics in Chinese Herbal Medicines: A Holism‐Based Review

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Phenolic antioxidants in CHMs mainly include chalcone, stilbene, flavonoid, xanthone, and Diels–Alder‐type adducts. They undergo direct and indirect pathways to exert antioxidant action. The indirect pathway is transition metal‐chelating, while the direct pathway comprises several redox‐based reactions (e.g., SET and HAT) and RAF reactions.
Xican Li
wiley   +1 more source

Clostridium sordellii necrotizing omphalitis: A case report and literature review

Journal of Pediatric Surgery Case Reports, 2016
Omphalitis is an infrequent neonatal infection of the umbilicus. Necrotizing infections are a rare complication of omphalitis that requires prompt antibiotic therapy, surgical debridement, and supportive care.
Eric J. Rellinger, Brian T. Craig, Laura D. Craig-Owens, M. Cristina Pacheco, Dai H. Chung, Melissa E. Danko   +5 more
doaj   +1 more source