Results 51 to 60 of about 6,597 (200)

VapC Toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins

, 2011
The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion are unknown.
Mizrahi, Valerie, Bhavna G Gordhan, Vickery Arcus, Diane Kuhnert, Valerie Mizrahi, Ahidjo, Bintou Ahmadou, Kuhnert, Diane, Edith E Machowski, Machowski E.E., Joanna L. Mckenzie, Garth L. Abrahams, Kuhnert D., Machowski Edith E., Abrahams, Garth L., Ahidjo B.A., Bintou Ahmadou Ahidjo, Gordhan, Bhavna G., Arcus V., Garth L Abrahams, Abrahams G.L., Machowski, Edith E., Mizrahi V., Kuhnert Diane, Ahidjo Bintou Ahmadou, McKenzie Joanna L., Arcus Vickery, Mizrahi Valerie, Edith E. Machowski, Abrahams Garth L., Gordhan B.G., McKenzie J.L., Gordhan Bhavna G., Bhavna G, Arcus, Vickery L., Bhavna G. Gordhan, McKenzie, Joanna Leigh, Joanna L McKenzie   +36 more
core   +1 more source

Genomic epidemiology and lineage‐specific risk stratification of tet(X4)‐mediated tigecycline resistance along the pork production chain: A One Health perspective

iMetaOmics, EarlyView.
Genome surveillance across a swine‐associated One Health continuum in China shows that slaughterhouses act as major enrichment nodes for tet(X4)‐mediated tigecycline resistance, driven by putative clonal transmission and stable plasmid backbones. Integrating global datasets enables lineage‐specific risk stratification, highlighting key control points ...
Qin Wang, Qiwu Yuan, Xuan Chen, Yujing Zhong, Ke Wu, Renqiao Wen, Luya Liu, Xiaoqin Wang, Cui Li, Hongning Wang, Changwei Lei   +10 more
wiley   +1 more source

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

Toxins, 2014
The hallmark of Mycobacterium tuberculosis is its ability to persist for a long-term in host granulomas, in a non-replicating and drug-tolerant state, and later awaken to cause disease.
Ambre Sala, Patricia Bordes, Pierre Genevaux   +2 more
doaj   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Clinical, hematological and biochemical studies on Envenomed horses [PDF]

Veterinary Medical Journal - Giza, 2017
The present studies were designed to investigate the impact of envenomation on the health and hematological parameters of horses. A total number of fifty-five native breed horses were examined in this study (twenty-one normal and healthy horses as ...
AbdelRahman Mahmoud, Hassan El Hamamsy, Sabry Mousa   +2 more
doaj   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Antitoxins

, 2008
openaire   +2 more sources

Diagnostic antibodies at an inflection point: From discovery platforms to design‐oriented engineering

VIEW, EarlyView.
This study systematically organizes the evolution of diagnostic antibodies from discovery platforms to design‐oriented engineering and analyzes the strengths and limitations of each approach. Meanwhile, it provides a critical, literature‐driven synthesis of current challenges, proposing integrated strategies for assay‐aware and function‐driven antibody
Qitao Song, Lulai Xu, Weilin Wu, Fei Xie, Yantong Pan, Tiantian Yang, Xiaoxia Xu, Yanyin Lin, Lihua Zhang, Jiahui Zhou, Junyou Zhou, Linping Li, Zhanhui Wang, Weijing Yi, Jing Wang   +14 more
wiley   +1 more source

Effect of cloned toxins, antitoxins and TA systems on the transformation rate into M. capricolum subsp. capricolum.

, 2021
(A) M. capricolum subsp. capricolum ATCC 27343T was transformed with different plasmid constructs harboring either entire TA operons (TA132/3, TA752/3 and TA160/1), individual toxins or antitoxins.
Martin Heller (168038), Hatice Akarsu (6635018), Virginia Hill (848245), Rubén Sánchez Barbarroja (11592819), Valentina L. Cippà (11592822), Peter Kuhnert (85859), Manfred Heller (128679), Michael H. Stoffel (6855809), Fabien Labroussaa (160578), Joerg Jores (168054), Laurent Falquet (158258)   +10 more
core   +1 more source