Results 61 to 70 of about 7,132 (197)

Detection of Clostridium tetani Neurotoxins Inhibited In Vivo by Botulinum Antitoxin B: Potential for Misleading Mouse Test Results in Food Controls

Toxins, 2018
The presence of botulinum neurotoxin-producing Clostridia (BPC) in food sources is a public health concern. In favorable environmental conditions, BPC can produce botulinum neurotoxins (BoNTs) outside or inside the vertebrate host, leading to ...
Luca Bano, Elena Tonon, Ilenia Drigo, Marco Pirazzini, Angela Guolo, Giovanni Farina, Fabrizio Agnoletti, Cesare Montecucco   +7 more
doaj   +1 more source

Integrative Modeling in the Age of Machine Learning: A Summary of HADDOCK Strategies in CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1746-1752, November 2026.
ABSTRACT The HADDOCK team participated in CAPRI rounds 47–55 as server, manual predictor, and scorers. Throughout these CAPRI rounds, we used a plethora of computational strategies to predict the structure of protein complexes. Of the 10 targets comprising 24 interfaces, we achieved acceptable or better models for 3 targets in the human category and 1 ...
Victor Reys, Marco Giulini, Vlad Cojocaru, Anna Engel, Xiaotong Xu, Jorge Roel‐Touris, Cunliang Geng, Francesco Ambrosetti, Brian Jiménez‐García, Zuzana Jandova, Panagiotis I. Koukos, Charlotte van Noort, João M. C. Teixeira, Siri C. van Keulen, Manon Réau, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +16 more
wiley   +1 more source

What is the link between stringent response, endoribonuclease encoding Type II Toxin-Antitoxin systems and persistence?

Frontiers in Microbiology, 2016
Persistence is a transient and non-inheritable tolerance to antibiotics by a small fraction of a bacterial population. One of the proposed determinants of bacterial persistence is toxin-antitoxin systems (TAS) which are also implicated in a wide range of
Bhaskar Chandra Mohan Ramisetty, Bhaskar Chandra Mohan Ramisetty, Dimpy Ghosh, Moumita Roy Chowdhury, Ramachandran Sarojini Santhosh   +4 more
doaj   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1813-1826, November 2026.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Toxins, Pathogenicity, Anti-Toxins, a Bicentennial Contribution

Toxins
The bicentenary of Louis Pasteur’s birth raises the opportunity to revisit the activity and influence of L [...]
Michel R. Popoff, Daniel Ladant
doaj   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 11, Page 1827-1835, November 2026.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, Volume 13, Issue 59, 23 October 2026.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin-antitoxin and related phage defense systems

, 2023
Toxin-antitoxin (TA) systems are a large group of small genetic modules found in prokaryotes and their mobile genetic elements. Type II TAs are encoded as bicistronic (two-gene) operons that encode two proteins: a toxin and a neutralizing antitoxin ...
Atkinson, Gemma C., Rustamova, Aytan,, Atkinson, Gemma Catherine, Chouhan, Bhanu,, Mets, Toomas, Duque-Pedraza, Julián, Tenson, Tanel,, Vasili Hauryliuk, Shenoy, Aditi,, Rustamova, Aytan, Bhanu Chouhan, Jose A. Nakamoto, Tetiana Brodiazhenko, Nakamoto, Jose A, Buttress, Jessica, Johansson, Marcus J. O., Egorov, Artyom, Nakamoto, Jose, Marcus J. O. Johansson, Buttress, Jessica A., Buttress, Jessica A,, Hauryliuk, Vasili, Atkinson, Gemma C,, Shyrokova, Lena, Jessica A. Buttress, Egorov, Artyom A,, Egorov, Artyom A., Saha, Chayan Kumar, Henrik Strahl, Ernits, Karin, Strahl, Henrik, Johansson, Marcus J O, Veda Bojar, Atkinson, Gemma C, Jelisaveta Džigurski, Lund University., Hauryliuk, Vasili,, Shenoy, Aditi, Brodiazhenko, Tetiana,, Shyrokova, Lena,, Arne Elofsson, Duque-Pedraza, Julián J,, Abel Garcia-Pino, Duque-Pedraza, Julián J., Brodiazhenko, Tetiana, Kurata, Tatsuaki, Aditi Shenoy, Tanel Tenson, Johansson, Marcus J O,, Kurata, Tatsuaki,, Buttress, Jessica A, Strahl, Henrik,, Elofsson, Arne,, Lena Shyrokova, Džigurski, Jelisaveta,, Chouhan, Bhanu, Karin Ernits, Toomas Mets, Mets, Toomas,, Tenson, Tanel, Garcia-Pino, Abel,, Julián J. Duque-Pedraza, Gemma C. Atkinson, Egorov, Artyom A, Nakamoto, Jose A,, Ernits, Karin,, Nakamoto, Jose A., Garcia-Pino, Abel, Elofsson, Arne, Džigurski, Jelisaveta, Artyom A. Egorov, Chayan Kumar Saha, Bojar, Veda, Bojar, Veda,, Duque-Pedraza, Julián J, Saha, Chayan Kumar,, Aytan Rustamova, Tatsuaki Kurata, Buttress, Jessica A.,, Atkinson, Gemma C.,, Nakamoto, Jose A.,, Egorov, Artyom A.,   +81 more
core   +1 more source

Development of an Innovative in Vitro Potency Assay for Anti-Botulinum Antitoxins

Toxins, 2016
Botulinum neurotoxins are bacterial proteins that cause botulism, a life-threatening disease. Therapy relies mostly on post-intoxication antibody treatment. The only accepted method to measure the potency of, and to approve, antitoxin preparations is the
Osnat Rosen, Eyal Ozeri, Ada Barnea, Alon Ben David, Ran Zichel   +4 more
doaj   +1 more source

Intrinsic Disorder as a New Frontier in Antimicrobial Resistance and Bacterial Fitness

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The works examines the link between intrinsic disorder in bacterial protein structure, and bacterial function, and antimicrobial resistance. It highlights how flexible, disordered proteins support secretion, stress responses, desiccation protection, and virulence, while also suggesting that these adaptable regions may provide novel targets for ...
Jack O' Callaghan, Michael P. Ryan, Sarah Hudson, Damien Thompson   +3 more
wiley   +1 more source