Results 121 to 130 of about 840,802 (388)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation

Drug Delivery, 2020
The aim of this work is to apply Solutol® HS15 and TPGS to prepare self-assembled micelles loading with ginsenoside Rh2 to increase the solubility of ginsenoside Rh2, hence, improving the antitumor efficacy.
Xiaojing Xia, Jin Tao, Zhuwa Ji, Chencheng Long, Ying Hu, Zhiying Zhao   +5 more
doaj   +1 more source

Response to “Radiation Therapeutic Gain and Asian Botanicals,” by Stephen Sagar [PDF]

, 2010
Numerous botanical agents, many of which are used in whole medical system practices (i.e. traditional Chinese medicine, Ayurvedic medicine, etc.), have been shown to exhibit radiomodifying effects on tumors and normal tissues in-vitro and invivo studies.
Lawenda, Brian D.
core   +1 more source

Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs

Nature Immunology, 2023
Tao Wang, Jinjing Zhang, Yanling Wang, Ying Li, Lu Wang, Yang Yu, Yushi Yao   +6 more
semanticscholar   +1 more source

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

Cell Death and Disease, 2018
It is now well established that cancer cells co-exist within a complex environment with stromal cells and depend for their growth and dissemination on tight and plastic interactions with components of the tumor microenvironment (TME). Cancer cells incite
Marco B. E. Schaaf, Abhishek D Garg, P. Agostinis   +2 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation

Signal Transduction and Targeted Therapy
Third-generation EGFR tyrosine kinase inhibitors (TKIs), exemplified by osimertinib, have demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer (NSCLC).
Tao Zhang, Zilu Pan, Jing Gao, Qingqing Wu, Gang Bai, Yan Li, Linjiang Tong, Fang Feng, Mengzhen Lai, Yingqiang Liu, Peiran Song, Yi Ning, Haotian Tang, Wen Luo, Yi Chen, Yan Fang, Hui Zhang, Qiupei Liu, Yudi Zhang, Hua Wang, Zhiwei Chen, Yi Chen, Meiyu Geng, Hongbin Ji, Guilong Zhao, Hu Zhou, Jian Ding, Hua Xie   +27 more
doaj   +1 more source

Myeloid suppressor cell depletion augments antitumor activity in lung cancer. [PDF]

, 2012
BackgroundMyeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine ...
Dubinett, Steven, Elashoff, David, Harris-White, Marni, Huang, Min, Johnson, Ming F, Kar, Upendra K, Lee, Jay M, Sharma, Sherven, Srivastava, Minu K, Strieter, Robert, Zhu, Li   +10 more
core   +3 more sources

Adenosine Deaminase 1 Overexpression Enhances the Antitumor Efficacy of Chimeric Antigen Receptor-Engineered T Cells

, 2021
Yun Qu, Zachary Spencer Dunn, Xianhui Chen, Melanie A. MacMullan, Gunce E. Cinay, Hsuan-Yao Wang, Jiangyue Liu, Fangheng Hu, Pin Wang   +8 more
openalex   +2 more sources

IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype

Cancer immunology research, 2019
IL15 promotes metabolically fit CAR-T cells with a lessdifferentiated stem cell memory phenotype. Addition of IL15 is a clinically translatable method for improving the antitumor function of ex vivo expanded CAR-T cells, which could improve outcomes for ...
D. Alizadeh, Robyn A. Wong, Xin Yang, Dongrui Wang, Joseph R. Pecoraro, C. Kuo, B. Aguilar, Y. Qi, D. Ann, R. Starr, Ryan Urak, Xiuli Wang, S. Forman, Christine E. Brown   +13 more
semanticscholar   +1 more source