Results 131 to 140 of about 491,510 (368)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG2000 micelles [PDF]

, 2013
Lulu Cai,1,* Neng Qiu,2,* Mingli Xiang,3,* Rongsheng Tong,1 Junfeng Yan,1 Lin He,1 Jianyou Shi,1 Tao Chen,4 Jiaolin Wen,3 Wenwen Wang,3 Lijuan Chen31Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital ...
Wen JL, Shi JY, He L, Chen LJ, Wang WW, Qiu N, Cai LL, Yan JF, Xiang ML, Tong RS, Chen T   +10 more
core  

Pharmaco-genomic characterization of pancreatic and biliary tract cancer tumoroids for drug response

iScience
Summary: Pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancer (BTC) are highly aggressive malignancies with limited therapeutic options. In this study, we established eleven tumoroids with paired patient-derived xenograft (PDX) models (five ...
Kun Fang, Wenxin Zhang, Qing Zhao, Yan Hong, Ruiqi Wang, Biyu Yang, Yangrong Zhao, Yunkai Shi, Bing Zhou, Jian Ding, Yanfen Fang, Yi Chen   +11 more
doaj   +1 more source

Adsorption of antitumor antibiotic doxorubicin on MCM-41-type silica surface [PDF]

, 2016
N. V. Roik, L. А. Belyakova, Marina O. Dziazko   +2 more
openalex   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

CIITA‐driven MHC‐II positive tumor cells: Preventive vaccines and superior generators of antitumor CD4⁺ T lymphocytes for immunotherapy [PDF]

, 2010
Valeria Frangione, Lorenzo Mortara, Patrizia Castellani, Andrea De Lerma Barbaro, Roberto S. Accolla   +4 more
openalex   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment [PDF]

, 2014
Kosuke Narise, Kensuke Okuda, Yukihiro Enomoto, Tasuku Hirayama, Hideko Nagasawa Laboratory of Pharmaceutical and Medicinal Chemistry, Gifu Pharmaceutical University, Daigaku-nishi, Gifu, Japan Abstract: Adaptive cellular responses resulting from ...
Hirayama T, Nagasawa H, Okuda K, Enomoto Y, Narise K   +4 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Carrier-free Peptide Co-assembled System with Synergistic Antitumor Effect Combines Immunotherapy and Sonodynamic Therapy [PDF]

Blocking programmed cell death ligand 1 (PD-L1) in tumor cells is an effective therapy strategy to achieve immune system activation for tumor therapy, however only a few patients can benefit from it.
Limin, Zhang, Weizhi, Wang
core   +1 more source