Results 241 to 250 of about 353,955 (311)
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu+14 more
wiley +1 more source
Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models. [PDF]
Ye J+19 more
europepmc +1 more source
Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou+8 more
wiley +1 more source
Multifaceted functions of tissue-resident memory T cells in tumorigenesis and cancer immunotherapy. [PDF]
Seo ES, Lee SK, Son YM.
europepmc +1 more source
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen+12 more
wiley +1 more source
Potentiation of cancer immunogenicity by targeting PARP. [PDF]
Humer D, Klepsch V, Baier G.
europepmc +1 more source
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui+19 more
wiley +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu+5 more
wiley +1 more source
Adoptively transferred macrophages for cancer immunotherapy. [PDF]
Park KS+8 more
europepmc +1 more source