Results 241 to 250 of about 840,802 (388)

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation.

Cancer Discovery, 2017
Jiehui Deng, Jiehui Deng, Eric S. Wang, R. Jenkins, Shuai Li, Ruben Dries, Kathleen B. Yates, Sandeep Chhabra, Wei Huang, Hongye Liu, A. Aref, E. Ivanova, C. Paweletz, M. Bowden, C. Zhou, G. Herter-Sprie, J. Sorrentino, J. Bisi, P. Lizotte, Ashley A. Merlino, Max M. Quinn, Lauren E. Bufe, A. Yang, Yanxi Zhang, Hua Zhang, P. Gao, Ting Chen, Megan E. Cavanaugh, Amanda J. Rode, Eric Haines, P. Roberts, J. Strum, W. Richards, J. Lorch, S. Parangi, Viswanath Gunda, G. Boland, R. Bueno, Sangeetha Palakurthi, Gordon J. Freeman, Gordon J. Freeman, J. Ritz, W. Haining, N. Sharpless, H. Arthanari, Geoffrey I. Shapiro, Geoffrey I. Shapiro, D. Barbie, D. Barbie, N. Gray, Kwok-kin Wong   +50 more
semanticscholar   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Safety and antitumor activity of recombinant soluble Apo2 ligand.

Journal of Clinical Investigation, 1999
A. Ashkenazi, R. Pai, S. Fong, Susan Leung, David A. Lawrence, S. Marsters, Christine Blackie, Ling Chang, Amy E. McMurtrey, Andrea Hebert, L. Deforge, I. Koumenis, D. Lewis, Louise A. Harris, J. Bussiere, H. Koeppen, Z. Shahrokh, R. Schwall   +17 more
semanticscholar   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Cuproptosis-triggering nanomedicine boosts antitumor immunotherapy. [PDF]

Theranostics
Wang M, Shi C, Shu Z, Li Z.
europepmc   +1 more source

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

, 1988
Yoshisuke Ozaki, Mark Edelstein, David S. Duch   +2 more
openalex   +2 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Cell-type specific activation of the cGAS-STING pathway in tumor immunotherapy: mechanisms and therapeutic implications. [PDF]

J Transl Med
Wang L, Zhu S, Ding Z, Hong J, Zheng L, Sun J, Tang Y, Chen X, Yong X, Hu M, Jiang Z, Liu Y, Wang D, Tang H.   +13 more
europepmc   +1 more source

Engineering a Sonotherapeutic RBC Membrane‐Derived Nanoparticle Platform for the Treatment of Liver Cancer

Advanced Functional Materials, EarlyView.
Herein, an RBC membrane‐derived nanoparticle (CMN‐ICG) is engineered to efficiently deliver a sonosensitizing agent, indocyanine green (ICG), for sonotherapy of hepatocellular carcinoma (HCC). CMN‐ICG exhibits excellent cytocompatibility, significantly enhances hepatocyte uptake, and produces excessive reactive oxygen species (ROS) upon ultrasound ...
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Juhi Bora, John Joseph Kelly, John Andrew Ronald, Arghya Paul   +6 more
wiley   +1 more source

Atrial arrhythmias related to antitumor treatment in patients with coronary heart disease and malignant tumors. [PDF]

Front Oncol
Zhang B, Zhang L, Ren Y, Xu C.
europepmc   +1 more source