Results 241 to 250 of about 491,510 (368)

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Docetaxel enhances Vβ-directed T-cell activation and antitumor immunity mediated by a bifunctional TCR agonist in breast and prostate cancer models. [PDF]

Front Immunol
Lee JK, Fabian KP, Santiago-Sanchez GS, Rosato F, Padget MR, Lee C, Su Z, Moisan J, Katragadda M, Schlom J, Gulley JL, Bayliffe A, Hodge JW.   +12 more
europepmc   +1 more source

Data Sheet 1_Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody.pdf

Jia-Xin Li (1489726), Shi-Yu Tan (21556103), Li-Qi Li (13861262), Yu-Hong Zheng (21556106), Lin Zhao (92451), Hui-Rong Zhu (15068265), Hai-Lang He (1792132), Yan-Yu Zhang (11870240), Run-Ze Li (8263305), Tian-Yu Bao (21556109), Yi-Zhong Zhang (21556142), Xiao-Man Yang (21556145), Hao Zhang (15339), Hui-Hui Chen (10779241), Bo-Wen Wu (6415742), Xin Lin (149944), Xiao-Sheng Lin (21104909), Yin Cheng Lin (21556148), Xin-Bing Sui (4869961), Ying Xie (50016), Xian-Mei Zhou (1792144), Pei-Yu Yan (10779253)   +21 more
openalex   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Limited Immune-Mediated Efficacy of Anti-PD-L1/VEGF in EGFR-TKI-Naïve <i>Egfr</i>-Mutant Lung Cancer with Non-Inflamed Tumor Microenvironment. [PDF]

Curr Oncol
Hirabae A, Kuribayashi T, Tomida S, Okawa S, Nakasuka T, Nishii K, Nishimura J, Makimoto G, Ninomiya K, Higo H, Rai K, Ichihara E, Hotta K, Sugimoto M, Togashi Y, Maeda Y, Kiura K, Ohashi K.   +17 more
europepmc   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

RETRACTION: Tanshinone sensitized the antitumor effects of irradiation on laryngeal cancer via JNK pathway. [PDF]

Cancer Med
europepmc   +1 more source

Heterogeneity of macrophages in PD-1/PD-L1 inhibitor therapy: a single-cell perspective. [PDF]

Cell Mol Biol Lett
Wu J, Zhou D, Jiang K, Li Z, Yao Y, Rao S, Yang X, Luo D.   +7 more
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Exercise-secreted antitumor myokines: mechanistic insights and translational potential. [PDF]

Front Sports Act Living
Han S, Du C, Zhao C, Zhang Q, Wu M, Yang C, Liu X.   +6 more
europepmc   +1 more source