Results 1 to 10 of about 34,745 (122)

RESEARCH PROGRESS IN INDIVIDUALIZED DRUG SCREENING TECHNOLOGY FOR PATIENTS WITH TUMORS [PDF]

精准医学杂志, 2023
In China, the incidence of tumors is increasing year by year, with the number of patients with new tumors ranking first in the world. Currently, tumors are usually treated with surgery combined with radiotherapy, chemotherapy, targeted therapy, or ...
WU Xiao-xiao, LIU Meiyou, PENG Li, CHENG Lianghua, WANG Fan, WANG Jingwen, JIA Yanyan
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Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To characterize the anatomy of the fruit and leaf and the presence of phytocompounds. To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L.
Bruna Lais Almeida Cunha, Jerônimo Pereira de França, Andrea Aparecida de Fátima Souza Moraes, Alba Lucilvânia Fonseca Chaves, Silvana Gaiba, Renato Fontana, Celio Kersul do Sacramento, Lydia Masako Ferreira, Lucimar Pereira de França   +8 more
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Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening.

PLoS ONE, 2021
This work tries to help overcome the lack of relevant translational screening assays, as a limitation for the identification of novel analgesics for neuropathic pain.
Antón L Martínez, José Brea, Mateo Barro, Xavier Monroy, Manuel Merlos, Javier Burgueño, María Isabel Loza   +6 more
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Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE:To evaluate the antitumor and antimicrobial activity of ethanolic extract of Morinda citrifolia L. fruit cultivated in southeastern Brazil.METHODS:Preparation ethanolic extract of the fruit of Morinda citrifoliaL.
Thamyris Candida, Jerônimo Pereira de França, Alba Lucilvânia Fonseca Chaves, Fernanda Andrade Rodrigues Lopes, Silvana Gaiba, Celio Kersul do Sacramento, Lydia Masako Ferreira, Lucimar Pereira de França   +7 more
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Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

Molecules, 2023
Imidazo[1,2-a]pyridines (IPs) have been studied regarding drug development. The objective of this work was to evaluate the antileukemic capacity of IP derivatives by screening their ability as a pro-oxidant.
Gabriella Teles Burkner, Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Júlia Papa de Araújo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Lígia Rodrigues Macedo, Edgar Julian Paredes-Gamero, Jamal Rafique, Eduardo Benedetti Parisotto   +14 more
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Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents

Frontiers in Chemistry, 2022
Ligustrazine (TMP) is a natural pyrazine alkaloid extracted from the roots of Ligusticum Chuanxiong Hort, which has the potential as an antitumor agent.
Shitang Ma, Shitang Ma, Shitang Ma, Ning Zhang, Jiafu Hou, Shijuan Liu, Jiawen Wang, Baowei Lu, Fucheng Zhu, Peipei Wei, Ge Hong, Tianjun Liu   +11 more
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Design and Validation of Experimental Setup for Cell Spheroid Radiofrequency-Induced Heating

Sensors, 2023
While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment
Ioannis Androulakis, Riccardo Ferrero, Rogier van Oossanen, Alessandra Manzin, Antonia G. Denkova, Kristina Djanashvili, Robin Nadar, Gerard C. van Rhoon   +7 more
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Advances in the application of high-throughput microfluidic platforms in precise diagnosis and treatment of tumors [PDF]

精准医学杂志
Although the treatment of malignant tumors has entered an era of comprehensive therapy integrating chemotherapy, targeted therapy, immunotherapy, and other modalities, there is still a significant gap from individualized precise treatment.
DOU Liliang, CHU Jiahui, LIU Lian
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Discovery of a Novel Potent Antitumor Molecule, P19G1, by Erlotinib Derivative Libraries Synthesized by Modular Click-Chemistry

Technology in Cancer Research & Treatment, 2022
Objective: Traditional chemical synthesis methods are cumbersome and inefficient. In this study, a novel antitumor molecule, 4-(4-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)phenyl sulfurofluoridate (P19G1), was ...
Qianfei Cui PhD, Peng Song PhD, Tiancheng Ma PhD, Zefeng Wang PhD, Xiaojing Lu MS, Yongjia Shi MS, Fang Zhang PhD, Guoqiang Lin PhD, Jiajia Dong PhD, Jiange Zhang PhD   +9 more
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Caracterización del perfil de sensibilidad de un panel de líneas celulares para valoración de citotoxicidad in vitro.

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La valoración de la citotoxicidad in vitro de líneas celulares derivadas de tumores humanos se emplea como bioensayo preliminar para el tamizaje de productos de origen natural con potencial actividad anticancerígena. Objetivo. Fortalecer el
Claudia Jhoana León, Sandra Milena Gómez, Sandra Johanna Morantes, Claudia Patricia Cordero, Fabio Ancízar Aristizábal   +4 more
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