Results 181 to 190 of about 758,251 (341)

Special Issue "Viral Infections: Physiology, Pathophysiology, Pathogenesis, Diagnosis and Treatment". [PDF]

Int J Mol Sci
Bażanów B, Stygar D.
europepmc   +1 more source

Additional file 2 of TRIM7 suppresses transmissible gastroenteritis virus replication by targeting the degradation of N protein and activating RIG-I-mediated type I IFN antiviral response

Qin, Weiyun, Xie, Yunxiao, Liang, Haijiang, Wu, Zuolin, Yang, Songbai, Zhou, Xiaolong, Zhao, Ayong   +6 more
openalex   +1 more source

Editorial Commentary: Does HIV Remain a Risk Factor for Achieving Sustained Virologic Response Under Direct Acting Antiviral-Based Modern Hepatitis C Virus Therapy? [PDF]

, 2014
Jürgen K. Rockstroh
openalex   +1 more source

Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides

Advanced Science, EarlyView.
To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li, Chenguang Yang, Ruihan Dong, Juan Francisco Bada Juarez, Lei Wang, Maximilian Emanuel Wettstein, Dali Wang, Chan Cao, Ying Lu, Chen Song   +9 more
wiley   +1 more source

Special Issue "Advances in Antiviral Agents Against SARS-CoV-2 and Its Variants" 2nd Edition. [PDF]

Viruses
Esposito F.
europepmc   +1 more source

Kinetic Insightsinto the Enhanced Antiviral Activityof Islatravir against Doravirine Resistance-Associated SubstitutionMutations in HIV‑1 Reverse Transcriptase

Nikita Zalenski (22154712), Derek J. Savoie (22154715), Amit Gaur (12240707), Neil A. Patel (22154718), David J. Suo (22154721), Turner W. Seay (22154724), Daniel Betancourt (22154727), Zucai Suo (258513)   +7 more
openalex   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Supplementary Materials for "Investigation of a clinical trial drug VV261 as a potent antiviral candidate against Chikungunya virus"

Yumin Zhang, Sheng Tang, Lu Chen
openalex   +1 more source

Detection of Hepatitis C Virus Resistant Mutants in the era of Direct Acting Antivirals [PDF]

, 2014
Lívia Maria Gonçalves Rossi, Paula Rahal   +1 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source