Results 181 to 190 of about 928,338 (389)
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure. [PDF]
, 2019 Hepatitis B virus (HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma (HCC).
Coben, Robert M. +7 more
core +1 more source
Advanced Science, EarlyView.Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu +18 more
wiley +1 more source
Antiviral and Antitumor Antibiotics. XX. Effects of Rotenone, Deguelin, and Related Compounds on Animal and Plant Viruses [PDF]
, 1969 Akira Takatsuki +7 more
openalex +2 more sources
Mode of Action of the Antiviral Activity of Amantadine in Tissue Culture [PDF]
, 1965 C. E. Hoffmann +3 more
openalex +1 more source
Advanced Science, EarlyView.Draper is evolutionarily conserved across most insect species. Loss of Draper inhibits autophagy activation, delaying middle silk gland degradation in the silkworm during metamorphosis. Draper interacts with autophagy ‐ related protein 3 (ATG3) to orchestrate autophagosome formation—a process essential for silk gland degradation during the larval‐pupal
Shiyu Zou +9 more
wiley +1 more source
Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
Science, 2004 S. Diebold +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.FA directly binds to residue H378 of DDX6 and promotes its interaction with HSC70, leading to CMA degradation of DDX6, thereby impairing GSK‐3β/β‐catenin signaling, inhibiting ABC transporter proteins, and enhancing chemosensitivity. Abstract ABC transporter protein‐mediated drug efflux is a significant contributor to induced resistance in breast ...
Xiaxia Fan +5 more
wiley +1 more source
Frontiers in Cellular NeuroscienceDue to the increased crewed spaceflights in recent years, it is vital to understand how the space environment affects human health. A lack of gravitational force is known to risk multiple physiological functions of astronauts, particularly damage to the ...
Zihan Li +7 more
doaj +1 more source