Results 121 to 130 of about 193,162 (335)
, 2015 Norovirus is one of the most common causes of acute viral gastroenteritis. The virus is spread via the fecal-oral route, most commonly from infected food and water, but several outbreaks have originated from contamination of surfaces with infectious ...
Keevil, C William +2 more
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Advanced Science, EarlyView.Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding +15 more
wiley +1 more source
Two ways to one goal: new strategy of antiviral therapy for chronic hepatitis C
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012 The aim of review. To analyze data of the clinical studies on chronic hepatitis C (CHC) treatment with application of new modes of combined therapy, including selective inhibitor of viral protease.Key points.
S. N. Batskikh
doaj
Remdesivir as a possible therapeutic option for the COVID-19 [PDF]
, 2020 Al-Homoud, Ali H. +2 more
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Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges [PDF]
, 2014 Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are
Dietrich, Isabelle +3 more
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Advanced Science, EarlyView.Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu +18 more
wiley +1 more source
Advanced Science, EarlyView.FA directly binds to residue H378 of DDX6 and promotes its interaction with HSC70, leading to CMA degradation of DDX6, thereby impairing GSK‐3β/β‐catenin signaling, inhibiting ABC transporter proteins, and enhancing chemosensitivity. Abstract ABC transporter protein‐mediated drug efflux is a significant contributor to induced resistance in breast ...
Xiaxia Fan +5 more
wiley +1 more source
c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-κB-mediated inflammation
Frontiers in ImmunologyIntroductionInhibiting viral replication and limiting NF-κB-driven inflammation simultaneously is essential for better antiviral therapy, highlighting the urgent need for a single agent that achieves both functions.MethodsHere, we reported NVP-BVU972 ...
Yunfei Xie +10 more
doaj +1 more source
Advanced Science, EarlyView.Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh +11 more
wiley +1 more source
Search for New Antiviral Agents-Part I. Synthesis of 2-phenyl-3-(alkyl-benzimidazolyl) quinazolin-4-ones [PDF]
, 1979 V. K. PANDEY, A. K. AGARWAL
openalex +1 more source