Results 141 to 150 of about 3,625,809 (366)

Short Term Evaluation of Outcomes of Accidental Pregnancy during Chronic Hepatitis C Treatment with Direct-Acting Antiviral Agents [PDF]

, 2023
Islam Mohamed Mahmoud Mohamed Yossef
openalex   +1 more source

Inactivation of murine norovirus on a range of copper alloy surfaces is accompanied by loss of capsid integrity

, 2015
Norovirus is one of the most common causes of acute viral gastroenteritis. The virus is spread via the fecal-oral route, most commonly from infected food and water, but several outbreaks have originated from contamination of surfaces with infectious ...
Keevil, C William, Summersgill, Emma N., Warnes, Sarah L.   +2 more
core   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain

Frontiers in Immunology, 2019
Innate immunity is critical in the early containment of influenza A virus (IAV) infection and surfactant protein D (SP-D) plays a crucial role in innate defense against IAV in the lungs.
Martin van Eijk, Marine L. B. Hillaire, Guus F. Rimmelzwaan, Michael J. Rynkiewicz, Mitchell R. White, Kevan L. Hartshorn, Martin Hessing, Peter A. Koolmees, Monique H. Tersteeg, Maarten H. van Es, Tjarko Meijerhof, Anke Huckriede, Henk P. Haagsman   +12 more
doaj   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

An orally available 4'-fluorouridine prodrug inhibits SFTSV and LCMV infection

Journal of Virology
Bunyaviruses, a subset of segmented negative-sense RNA viruses, include pathogenic species capable of zoonotic transmission to humans via arthropod vectors and rodent hosts.
Xiaoqin Jian, Tianwen Hu, Huan Xu, Yuxi Wen, Yumin Zhang, Mengwei Xu, Xiaming Jiang, Junyuan Cao, Li Xiang, Jingshan Shen, Guanghui Tian, Gengfu Xiao, Leike Zhang   +12 more
doaj   +1 more source

Drug–Drug Interactions of Newly Approved Direct-Acting Antiviral Agents in Patients with Hepatitis C

, 2021
Lu-Hua Gao, Qing‐He Nie, X. Zhao
openalex   +2 more sources

Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]

, 2018
Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core   +1 more source

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

Development of a Mass Antiviral Screening System Using Viral Hemorrhagic Septicemia Virus as an RNA Surrogate and Activity Confirmation with a Fish Rhabdovirus

Viruses
With emerging viruses and drug resistance on the rise, the discovery and development of innovative antiviral substances and agents are necessary for the effective treatment and control of viral outbreaks.
Ji Woo Shin, Su Yeon Kim, Min Jeong Kim, Taek-Kyun Lee, Tae-Jin Choi   +4 more
doaj   +1 more source