Results 21 to 30 of about 111,478 (253)

Antiviral Potential of Nanoparticles—Can Nanoparticles Fight Against Coronaviruses?

Nanomaterials, 2020
Infectious diseases account for more than 20% of global mortality and viruses are responsible for about one-third of these deaths. Highly infectious viral diseases such as severe acute respiratory (SARS), Middle East respiratory syndrome (MERS) and ...
Sangiliyandi Gurunathan, Muhammad Qasim, Youngsok Choi, Jeong Tae Do, Chankyu Park, Kwonho Hong, Jin-Hoi Kim, Hyuk Song   +7 more
doaj   +1 more source

Recent Research Progress: Discovery of Anti-Plant Virus Agents Based on Natural Scaffold

Frontiers in Chemistry, 2022
Plant virus diseases, also known as “plant cancers”, cause serious harm to the agriculture of the world and huge economic losses every year. Antiviral agents are one of the most effective ways to control plant virus diseases.
Jixiang Chen, Xin Luo, Yifang Chen, Yu Wang, Ju Peng, Ju Peng, Zhifu Xing   +6 more
doaj   +1 more source

In ovo Antiviral Screening of Four Nigerian Medicinal Plants (Artemisia absinthium L., Annona senegalensis Pers., Erythrina senegalensis DC., and Jatropha curcas L.) Against Newcastle Disease Virus [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: Newcastle disease virus (NDV) poses a major threat to global poultry production, driving interest in novel plant-based antiviral agents.
Sylvester Nefai Mathias, Emmanuel Halilu Mshelia, Chinenye Jane Ugwah-Oguejiofor, Ibrahim Yusuf Alkali, Aminu Ahmed Biambo, Mansur Lawal, Aliyu Hamidu Ahmed   +6 more
doaj   +1 more source

Rapid Degradation of SARS-CoV-2 Spike S Protein by A Specific Serine Protease

Molecules, 2022
The S protein of SARS-CoV-2 is a crucial structural and functional component for virus entry. Due to the constant mutation of the virus, there are very limited ways to prevent and control COVID-19.
Jiankai Liu, Mujie Kan, Lianzhi Zhang, Yuan Yue, Shaohua Wang, Min Hong, Xinyu Hong   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Potent Antiviral Activity of Vitamin B12 against Severe Acute Respiratory Syndrome Coronavirus 2, Middle East Respiratory Syndrome Coronavirus, and Human Coronavirus 229E

Microorganisms, 2023
Repurposing vitamins as antiviral supporting agents is a rapid approach used to control emerging viral infections. Although there is considerable evidence supporting the use of vitamin supplementation in viral infections, including severe acute ...
Yassmin Moatasim, Omnia Kutkat, Ahmed M. Osman, Mokhtar R. Gomaa, Faten Okda, Mohamed El Sayes, Mina Nabil Kamel, Mohamed Gaballah, Ahmed Mostafa, Rabeh El-Shesheny, Ghazi Kayali, Mohamed A. Ali, Ahmed Kandeil   +12 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A Novel Intronic Circular RNA Antagonizes Influenza Virus by Absorbing a microRNA That Degrades CREBBP and Accelerating IFN-β Production

mBio, 2021
Virus-host interactions are complicated processes, and multiple cellular proteins promote or inhibit viral replication through different mechanisms. Recent progress has implicated circular RNAs (circRNAs) in cancer biology and progression; however, the ...
Zhiyuan Qu, Fei Meng, Jianzhong Shi, Guohua Deng, Xianying Zeng, Jinying Ge, Yanbing Li, Liling Liu, Pucheng Chen, Yongping Jiang, Chengjun Li, Hualan Chen   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source