Results 51 to 60 of about 3,625,809 (366)

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Science, 2020
Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments.
Wenhao Dai, Bing Zhang, Xiaming Jiang, H. Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Z. Rao, Lei-ke Zhang, Yechun Xu, Haitao Yang, Hong Liu   +26 more
semanticscholar   +1 more source

Discovery of Retro-1 Analogs Exhibiting Enhanced Anti-vaccinia Virus Activity

Frontiers in Microbiology, 2020
Orthopoxviruses (OPXVs) are an increasing threat to human health due to the growing population of OPXV-naive individuals after the discontinuation of routine smallpox vaccination.
Lalita Priyamvada, Philip Alabi, Andres Leon, Amrita Kumar, Suryaprakash Sambhara, Victoria A. Olson, Jason K. Sello, Panayampalli S. Satheshkumar   +7 more
doaj   +1 more source

Synthesis and Antiviral Activity of Camphene Derivatives against Different Types of Viruses

Molecules, 2021
To date, the ‘one bug-one drug’ approach to antiviral drug development cannot effectively respond to the constant threat posed by an increasing diversity of viruses causing outbreaks of viral infections that turn out to be pathogenic for humans ...
Anastasiya S. Sokolova, Valentina P. Putilova, Olga I. Yarovaya, Anastasiya V. Zybkina, Ekaterina D. Mordvinova, Anna V. Zaykovskaya, Dmitriy N. Shcherbakov, Iana R. Orshanskaya, Ekaterina O. Sinegubova, Iana L. Esaulkova, Sophia S. Borisevich, Nikolay I. Bormotov, Larisa N. Shishkina, Vladimir V. Zarubaev, Oleg V. Pyankov, Rinat A. Maksyutov, Nariman F. Salakhutdinov   +16 more
doaj   +1 more source

Ribonuclease from Bacillus Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses

BioMed Research International, 2017
Bacillus pumilus ribonuclease (binase) was shown to be a promising antiviral agent in animal models and cell cultures. However, the mode of its antiviral action remains unknown.
R. Shah Mahmud, Christin Müller, Y. Romanova, A. Mostafa, V. Ulyanova, S. Pleschka, O. Ilinskaya   +6 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interferon free antiviral treatment of chronic hepatitis C in patients affected by β-thalassemia major [PDF]

, 2017
Chronic hepatitis C (CHC) significantly affects the prognosis of liver disease [1] and health related quality of life (HRQOL) in patients with β-thalassemia major [2, 3].
Biliotti, Elisa, Esvan, Rozenn, Franchi, Cristiana, Palazzo, Donatella, Serani, Marco, Silvestri, Alessandro M., Sorrentino, Francesco, Spaziante, Martina, Taliani, Gloria, Volpicelli, Lorenzo   +9 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Biological Activities of Extracts from Sumac (Rhus spp.): A Review [PDF]

, 2007
Sumac is the common name for a genus (Rhus) that contains over 250 individual species of flowering plants in the family Anacardiaceae. These plants are found in temperate and tropical regions worldwide, often grow in areas of marginal agricultural ...
Giuseppe Mazza, Sierra Rayne
core   +2 more sources

Antioxidant Capacity and Antimicrobial Activity of Commercial Samples of Guava Leaves (\u3cem\u3ePsidium guajava\u3c/em\u3e) [PDF]

, 2020
Psidium guajava is a small tree native to South and Central America. Guava leaves have traditionally been used for treating different illnesses. These benefits can be attributed to phenolics and flavonoids produced by guava.
Alsaidi, Sahar, Bonnaire, Thierry, Cornejal, Nadjet, Cruz Rodriguez, Gearoff, Cruz, Victor, Fernandez Romero, Jose, Gomez Ramirez, Aned, Koroch, Adolfina, Melo, Claudia, Priano, Christine, Sorel, Victor, Zydowsky, Thomas M   +11 more
core   +2 more sources

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Antioxidants, 2020
Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects.
Shokoh Parham, Anousheh Zargar Kharazi, H. R. Bakhsheshi‐Rad, Hadi Nur, A. Ismail, S. Sharif, S. Ramakrishna, F. Berto   +7 more
semanticscholar   +1 more source