Results 71 to 80 of about 3,625,809 (366)

Identification of Antiviral Agents Targeting Hepatitis B Virus Promoter from Extracts of Indonesian Marine Organisms by a Novel Cell-Based Screening Assay

Marine Drugs, 2015
The current treatments of chronic hepatitis B (CHB) face a limited choice of vaccine, antibody and antiviral agents. The development of additional antiviral agents is still needed for improvement of CHB therapy.
Atsuya Yamashita, Yuusuke Fujimoto, Mayumi Tamaki, Andi Setiawan, Tomohisa Tanaka, Kaori Okuyama-Dobashi, Hirotake Kasai, Koichi Watashi, Takaji Wakita, Masaaki Toyama, Masanori Baba, Nicole J. de Voogd, Shinya Maekawa, Nobuyuki Enomoto, Junichi Tanaka, Kohji Moriishi   +15 more
doaj   +1 more source

The influence of risk perception in epidemics: a cellular agent model [PDF]

, 2006
Our work stems from the consideration that the spreading of a disease is modulated by the individual's perception of the infected neighborhood and his/her strategy to avoid being infected as well.
E. Domany, F. Liljeros, J.D. Murray, J.S. Brownstein, M. Bloch, P.M. Zanotto, R.M. Anderson   +6 more
core   +2 more sources

Direct Binding of Ledipasvir to HCV NS5A: Mechanism of Resistance to an HCV Antiviral Agent

PLoS ONE, 2015
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer resistance to ledipasvir in HCV replicon cells ...
H. Kwon, Weimei Xing, Katie Chan, A. Niedziela-Majka, K. Brendza, T. Kirschberg, Darryl Kato, J. Link, G. Cheng, Xiaohong Liu, R. Sakowicz   +10 more
semanticscholar   +1 more source

Adult‐Onset Subacute Sclerosing Panencephalitis Presenting With Subacute Cognitive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We describe the case of a 41‐year‐old man diagnosed with adult‐onset subacute sclerosing panencephalitis (SSPE). The patient presented with subacute progressive cognitive deficits and a neuropsychological profile indicating predominant frontoparietal dysfunction. MRI showed only mild parietal‐predominant cerebral atrophy.
Dennis Yeow, Nicola McKern, Vincent Oxenham, Kate Ahmad, Omar Ahmad   +4 more
wiley   +1 more source

Antiviral Agents as Therapeutic Strategies Against Cytomegalovirus Infections

Viruses, 2019
Cytomegalovirus (CMV) is a threat to human health in the world, particularly for immunologically weak patients. CMV may cause opportunistic infections, congenital infections and central nervous system infections. CMV infections are difficult to treat due
Shiu-Jau Chen, Shao-Cheng Wang, Yuan-Chuan Chen   +2 more
doaj   +1 more source

Repurposing of Doramectin as a New Anti-Zika Virus Agent

Viruses, 2023
Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes, causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly, and meningoencephalitis.
Yujia Zhu, Minqi Liang, Jianchen Yu, Bingzhi Zhang, Ge Zhu, Yun Huang, Zhenjian He, Jie Yuan   +7 more
doaj   +1 more source

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

Viruses, 2015
Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection,
Wenjiao Wu, Richan Li, Xianglian Li, Jian He, Shibo Jiang, Shuwen Liu, Jie Yang   +6 more
semanticscholar   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Preparation and characterization of biodegradable polyester fibers enhanced with antibacterial and antiviral organic composites

e-Polymers
The addition of biodegradable agents and antibacterial and antiviral modifiers in polyester fibers makes the fabric skin-friendly and helps in the effective biodegradation of the fabric, thereby protecting the ecological environment.
Gong Xiaorong, Zhang Shouyun, Xie Lingye, Zhang Yang, Cheng Ruijia, Chen Yuting   +5 more
doaj   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source