Results 131 to 140 of about 286,395 (314)
Advanced Science, EarlyView.Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu +18 more
wiley +1 more source
The need for new antiviral agents
Antiviral Research, 1985 Population density and immune status, vectors and virulence of infection, nutritional status, sanitation, genetic susceptibility and medical management of cases, are important factors influencing the incidence and/or severity of virus infections. Thus, the prevalence and clinical importance of virus infections and the need for antiviral drugs differ ...
openaire +3 more sources
Advanced Science, EarlyView.Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh +11 more
wiley +1 more source
Search for New Antiviral Agents. Part. I. Synthesis of Aryl Sulfamoyl Benzamido Alkyl/Aralkyl Esters [PDF]
, 1974 VINAY S. MISRA, MANJU VARSHNEYA
openalex +1 more source
Advanced Science, EarlyView.This study explores honeysuckle‐derived nanovesicles (HNVs) for treating inflammatory bowel disease. Orally administered HNVs alleviates colitis in mice by repairing the gut barrier, reducing inflammation, and restoring a healthy gut microbiota.
Yuanyuan Wang +11 more
wiley +1 more source
Post‐Translational Modifications of TOE3 Regulate Antiviral Defense in Tobacco
Advanced Science, EarlyView.CK2αL phosphorylates TOE3 and enhances its stability, while FBXL1 promotes the ubiquitination‐degradation of TOE3 via the 26S proteasome. Compared to CK2αL‐phosphorylated TOE3, nonphosphorylated TOE3 shows a much higher affinity for FBXL1 and is more susceptible to ubiquitination‐degradation, thus facilitating viral infection. The regulatory mechanisms
Bolei Jiao +3 more
wiley +1 more source
Mechanism of Host Defense Suppression Induced by Viral Infection: Mode of Action of Inosiplex as an Antiviral Agent [PDF]
, 1982 Haruo Ohnishi +6 more
openalex +1 more source
Advanced Science, EarlyView.Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu +25 more
wiley +1 more source
Enhancement of activity against influenza viruses by combinations of antiviral agents [PDF]
, 1980 Frederick G. Hayden +2 more
openalex +1 more source
Antiviral treatment for chronic hepatitis B [PDF]
, 1997 An updated review of the antiviral agents currently available or under trial for the treatment of chronic hepatitis B is presented. There are two broad groups: (1) immunomodulators including interferon α (which also has a direct antiviral effect ...
Lai, CL, Wu, PC
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