International Journal of Cancer, EarlyView.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents. [PDF]
ACS Chem NeurosciJones T +7 more
europepmc +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Human papillomavirus (HPV), the necessary cause of cervical cancer, is associated with an increased risk of other anogenital cancers. While HPV has frequently been detected in prostate specimens, its role in prostate carcinogenesis remains controversial. We synthesized and meta‐analyzed the epidemiological literature on the association between
Sarah Botting‐Provost +5 more
wiley +1 more source
Current antiviral agents against human adenoviruses associated with respiratory infections. [PDF]
Front PediatrLi L, Xie Z, Xu L.
europepmc +1 more source
International Journal of Cancer, EarlyView.ABSTRACT People with HIV (PWH) are living longer, but contemporary data on non–AIDS‐defining cancers (NADCs) in Italy remain limited. We assessed incident cancers in a retrospective cohort of PWH in Milan, Italy, between January 2000 and December 2023. Follow‐up was grouped into 2000–2007, 2008–2015, and 2016–2023. Incidence rates (IRs) were calculated
Giacomo Pozza +14 more
wiley +1 more source
Potential Broad-Spectrum Antiviral Agents: A Key Arsenal Against Newly Emerging and Reemerging Respiratory RNA Viruses. [PDF]
Int J Mol SciLuong QXT +5 more
europepmc +1 more source
Microbiome‐mediated plant‐soil feedbacks as a tool for resilient agriculture
iMetaOmics, EarlyView.Translating plant‐soil feedbacks (PSFs) into reliable agricultural management requires shifting from input‐dependent practices toward endogenous, process‐driven crop resilience. To bridge this gap, we propose a predictive framework centered on three strategic interventions: engineering the crop holobiont, diversifying the soil habitat, and deploying ...
Muhammad Asif +4 more
wiley +1 more source
Antiviral Agents for Preventing Cytomegalovirus Disease in Recipients of Hematopoietic Cell Transplantation. [PDF]
VirusesJaing TH, Wang YL, Chiu CC.
europepmc +1 more source
Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
iMetaOmics, EarlyView.In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang +19 more
wiley +1 more source
Visible-Light-Driven Photocatalyst-Free Multicomponent Reactions: Green Synthesis of Tetraketones as Potent Antiviral Agents through Virtual Screening, Molecular Docking, and MD Simulations. [PDF]
ACS OmegaAcharya SS +6 more
europepmc +1 more source