Results 81 to 90 of about 4,080,754 (294)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li +11 more
wiley +1 more source
Advanced Materials, EarlyView.Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa +6 more
wiley +1 more source
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
Phytochemicals as Antiviral Agents: Recent Updates
Plant-derived Bioactives, 2020 The epidemic of viral diseases is a global concern, mandating an urgent need of most promising antivirals. Some of the viral diseases can be cured by approved antiviral drugs, but for others still do not have any vaccines or drugs available.
R. Ghildiyal +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
MODERN CONCEPTS OF FARMACOTHERAPY OF HERPES ZOSTER [PDF]
Саратовский научно-медицинский журнал, 2008 In the reviewofmodern concept ofpathology and pharmacotherapyofherpes zostervirus were analyzed. Complex therapy of varicella-zoster virus includes antiviral, immunobiological agents and drugs, affecting pathogenesis of the disease.
A.L. Bakulev +2 more
doaj
New antiviral agents and new treatments on the horizon for the management of viral hepatitis
Thalassemia Reports, 2011 Transfusion dependant patients are at risk of acquiring transfusiontransmitted viral infections including Hepatitis B virus (HBV) and Hepatitis C (HCV). These infections can lead to cirrhosis and hepatic cancer. Standard treatment, although with improved
M. Sönmezoğlu
doaj +1 more source
Moringa oleifera Lam. and derived phytochemicals as promising antiviral agents: A review
, 2020 Frequent use of medicinal plants is common in healthcare needs of mankind since ancient ages. Among these Moringa oleifera Lam. is one of the vastly used plant whose various parts (leaf, fruit, seeds etc.) are included in regular diet for their multiple ...
D. Biswas +4 more
semanticscholar +1 more source
Molecules, 2020 Respiratory RNA viruses are responsible for recurrent acute respiratory illnesses that still represent a major medical need. Previously we developed a large variety of benzimidazole derivatives able to inhibit these viruses.
Valeria Francesconi +4 more
semanticscholar +1 more source