Results 161 to 170 of about 4,144,524 (396)

Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro [PDF]

, 1992
Robert Snoeck, Graciela Andreï, Dominique Schols, Jan Balzarini, Erik De Clercq   +4 more
openalex   +1 more source

Fusidic Acid Reverses Chemoresistance in Breast Cancer via Targeting DDX6 to Downregulate GSK‐3β/β‐Catenin Signaling

Advanced Science, EarlyView.
FA directly binds to residue H378 of DDX6 and promotes its interaction with HSC70, leading to CMA degradation of DDX6, thereby impairing GSK‐3β/β‐catenin signaling, inhibiting ABC transporter proteins, and enhancing chemosensitivity. Abstract ABC transporter protein‐mediated drug efflux is a significant contributor to induced resistance in breast ...
Xiaxia Fan, Dan Guo, Songtao Li, Jinmiao Tian, Chaotong Zhang, Zhuoyu Li   +5 more
wiley   +1 more source

Mycophenolate mofetil exerts broad-spectrum antiviral activity against coronaviruses including SARS-CoV-2

Virology Journal
Background New anti-coronavirus drugs are continuously being developed to address the serious long-term challenge posed by numerous SARS-CoV-2 variants.
Mengyuan Wu, Kun Wang, Huiqiang Wang, Haiyan Yan, Shuo Wu, Ge Yang, Yuhuan Li, Yongsheng Che, Jiandong Jiang   +8 more
doaj   +1 more source

Antiviral drug sensitivity in ocular herpes simplex virus infection. [PDF]

, 1990
M J Ménage, Erik De Clercq, A van Lierde, V S Easty, J. M. Darville, S. D. Cook, D L Easty   +6 more
openalex   +1 more source

Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model

Computational and Structural Biotechnology Journal, 2020
B. Beck, Bonggun Shin, Yoonjung Choi, Sungsoo Park, Keunsoo Kang   +4 more
semanticscholar   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

Advanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh, Albert Kallon Koroma, Rajeev Kumar Pandey, Yongfang Wang, Jinnan Cheng, Philipp Haas, Mahyar Aghapour, Linda Krug, Adelheid Hainzl, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter‐Kochanek   +11 more
wiley   +1 more source

Ultrasound‐Responsive HBD Peptide Hydrogel with Antibiofilm Capability for Fast Diabetic Wound Healing

Advanced Science
Despite advancements in therapeutic agents for diabetic chronic wounds, challenges such as suboptimal bioavailability, intricate disease milieus, and inadequate delivery efficacy have impeded treatment outcomes.
Lanlan Zong, Runxin Teng, Huiqi Zhang, Wenshang Liu, Yu Feng, Zhengmao Lu, Yuxiao Zhou, Zhen Fan, Meng Li, Xiaohui Pu   +9 more
doaj   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects [PDF]

, 2017
Diamond, Michael S, et al,, Govero, Jennifer   +2 more
core   +2 more sources