Results 321 to 330 of about 4,144,524 (396)

C‐6‐Modified 2‐F‐Fucose Derivatives as Inhibitors of Fucosyltransferases

ChemBioChem, EarlyView.
A series of C6‐modified guanosine‐diphosphate‐2‐F‐fucose analogs and corresponding prodrugs are designed, synthesized, and biologically evaluated as inhibitors of cellular fucosylation. Certain analogs potently inhibit fucosyltransferases (FUT) FUT1, 3, 6, and 9 while showing minimal activity for FUT8, highlighting the potential for selective FUT ...
Yanyan Liu, Geert‐Jan Boons
wiley   +1 more source

Flow analysis-solid phase extraction system and UHPLC-MS/MS analytical methodology for the determination of antiviral drugs in surface water. [PDF]

Environ Sci Pollut Res Int
Mermer K, Jas E, Paluch J, Woźniakiewicz A, Woźniakiewicz M, Miśkowiec P, Chocholouš P, Sklenářová H, Kozak J.   +8 more
europepmc   +1 more source

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

ChemCatChem, EarlyView.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen, Santipap Chaiyasarn, Zheng Guo, Jaehong Han, Bekir Engin Eser   +4 more
wiley   +1 more source

A Tale of Two Designs: Comparing Design of Experiment Strategies for Reaction Optimization

Chemistry–Methods, EarlyView.
The application of Design of Experiments (DoE) significantly accelerates the optimization of reaction conditions for previously unreported transformations. DoE achieves this by focusing experimental efforts, enabling efficient exploration of the so‐called experimental space.
Linda Romano, Veronica Ceccucci, Leonardo Tensi, Claudio Santi, Luca Sancineto   +4 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Molecular modeling of some commercially available antiviral drugs and their derivatives against SARS-CoV-2 infection. [PDF]

Narra J
Arman M, Alam S, Maruf RA, Shams Z, Islam MN.   +4 more
europepmc   +1 more source

Exploring Antiviral Drugs on Monolayer Black Phosphorene: Atomistic Theory and Explainable Machine Learning-Assisted Platform. [PDF]

Int J Mol Sci
Laref S, Harrou F, Sun Y, Gao X, Gojobori T.   +4 more
europepmc   +1 more source

A Real-World Retrospective Study on the Efficacy and Safety of Four Antiviral Drugs for Hospitalized COVID-19 Patients: Nirmatrelvir/Ritonavir, Simnotrelvir/Ritonavir, Molnupiravir and Azvudine. [PDF]

Infect Drug Resist
Yu X, Luo R, Xie G, Ji J, Wang J, Li X, Qian X, Wang X.   +7 more
europepmc   +1 more source