Results 341 to 350 of about 4,144,524 (396)
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Reviews in Medical Virology, 2021
Mitogen‐activated protein kinases (MAPKs) play a key role in complex cellular processes such as proliferation, development, differentiation, transformation and apoptosis.
Y. Chander +6 more
semanticscholar +1 more source
Mitogen‐activated protein kinases (MAPKs) play a key role in complex cellular processes such as proliferation, development, differentiation, transformation and apoptosis.
Y. Chander +6 more
semanticscholar +1 more source
Pharmaceutisch Weekblad, 1991
There are only a limited number of effective, non-toxic antiviral drugs for clinical use, whereas there is a great need for such drugs. Especially for the treatment of patients infected with the human immuno-deficiency virus (HIV) anti-HIV drugs are required. At the same time viral infections secondary to AIDS cannot yet be treated effectively.
R. Janknegt, E. H. H. Wiltink
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There are only a limited number of effective, non-toxic antiviral drugs for clinical use, whereas there is a great need for such drugs. Especially for the treatment of patients infected with the human immuno-deficiency virus (HIV) anti-HIV drugs are required. At the same time viral infections secondary to AIDS cannot yet be treated effectively.
R. Janknegt, E. H. H. Wiltink
openaire +3 more sources
Drug Interactions with Antiviral Drugs
Clinical Pharmacokinetics, 1996Antiviral drug interactions are a particular problem among immuno-compromised patients because these patients are often receiving multiple different drugs, i.e. antiretroviral drugs and drugs effective against herpesvirus. The combination of zidovudine and other antiretroviral drugs with different adverse event profiles, such as didanosine, zalcitabine
Eric Singlas, Anne-Marie Taburet
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Current Medicinal Chemistry, 2020
Here we report on the most recent updates on experimental drugs successfully employed in the treatment of the disease caused by SARS CoV-2 coronavirus, also referred to as COVID-19 (COronaVIrus Disease 19).
M. Costanzo +2 more
semanticscholar +1 more source
Here we report on the most recent updates on experimental drugs successfully employed in the treatment of the disease caused by SARS CoV-2 coronavirus, also referred to as COVID-19 (COronaVIrus Disease 19).
M. Costanzo +2 more
semanticscholar +1 more source
2015
The Side Effects of Drugs Annuals are a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. This review of the January 2015 to December 2015 publications on antiviral drugs includes drugs that are active against cytomegalovirus (cidofovir, foscarnet, ganciclovir and valganciclovir), drugs that are active ...
Sreekumar Othumpangat +2 more
openaire +4 more sources
The Side Effects of Drugs Annuals are a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. This review of the January 2015 to December 2015 publications on antiviral drugs includes drugs that are active against cytomegalovirus (cidofovir, foscarnet, ganciclovir and valganciclovir), drugs that are active ...
Sreekumar Othumpangat +2 more
openaire +4 more sources
Trends in Pharmacological Sciences, 1989
Recently the first report of zidovudine-resistant human immunodeficiency virus obtained from AIDS patients was published. Resistance to antiviral agents may result from single point mutations in the virus genome. Several mechanisms of resistance have already been elucidated at the biochemical level but the clinical significance of drug resistance is ...
Siân E. Goldthorpe, Hugh J. Field
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Recently the first report of zidovudine-resistant human immunodeficiency virus obtained from AIDS patients was published. Resistance to antiviral agents may result from single point mutations in the virus genome. Several mechanisms of resistance have already been elucidated at the biochemical level but the clinical significance of drug resistance is ...
Siân E. Goldthorpe, Hugh J. Field
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The use of antiviral drugs in children
Journal of Chemotherapy, 2021Viral infections are particularly common among children. They often have a mild course, are self-limiting and do not need any specific treatment. However, in some cases, the disease can be severe and lead to permanent disabilities. A variety of antiviral drugs are available for the treatments of certain infectious agents: for instance, acyclovir is ...
Motisi M. A. +5 more
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Archives of Pediatrics & Adolescent Medicine, 1989
Pediatricians are made familiar with antiviral drugs and are provided with specific recommendations for treatment of viral diseases. The antiviral drugs in clinical use today are discussed in terms of their doses, routes of administration, mechanisms of action, established and potential efficacies, and toxicities.
Janet A. Englund, Henry H. Balfour
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Pediatricians are made familiar with antiviral drugs and are provided with specific recommendations for treatment of viral diseases. The antiviral drugs in clinical use today are discussed in terms of their doses, routes of administration, mechanisms of action, established and potential efficacies, and toxicities.
Janet A. Englund, Henry H. Balfour
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Fifty Years in Search of Selective Antiviral Drugs.
Journal of Medicinal Chemistry, 2019Fifty years of research (1968-2018) toward the identification of selective antiviral drugs have been primarily focused on antiviral compounds active against DNA viruses (HSV, VZV, CMV, HBV) and retroviruses (HIV).
E. De Clercq
semanticscholar +1 more source
Antiviral Research, 2006
Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
openaire +3 more sources
Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
openaire +3 more sources