Results 51 to 60 of about 4,679,298 (290)

Potential Antiviral Drugs for SARS-Cov-2 Treatment: Preclinical Findings and Ongoing Clinical Research.

In Vivo, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), initially termed 2019-new CoV (2019-nCoV), is a novel coronavirus responsible for the severe respiratory illness currently ongoing worldwide from the beginning of December 2019. This beta gene
S. Bimonte, A. Crispo, A. Amore, E. Celentano, A. Cuomo, M. Cascella   +5 more
semanticscholar   +1 more source

Highlights in Antiviral Drug Research: Antivirals at the Horizon [PDF]

Medicinal Research Reviews, 2012
AbstractThis review highlights ten “hot topics” in current antiviral research: (i) new nucleoside derivatives (i.e., PSI‐352938) showing high potential as a direct antiviral against hepatitis C virus (HCV); (ii) cyclopropavir, which should be further pursued for treatment of human cytomegalovirus (HCMV) infections; (iii) North‐methanocarbathymidine (N ...
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Prediction of baseline oral microbiota for clinical classification post Omicron variant of SARS-CoV-2 infection

Scientific Reports
Oral microbiota is related to the severity and recovery of SARS-CoV-2 infection. This study aims to predict clinical classification after SARS-CoV-2 infection using oral microbiota before infection.
Junyi Sun, Shanshuo Liu, Daming Wang, Jia Yu, Bowen Liu, Hong Luo, Feng Gao, Yawen Zou, Ying Sun, Haiyu Wang, Xueping Wang, Yongjian Zhou, Lei Li, Zhongwen Wu, Zujiang Yu, Zhigang Ren   +15 more
doaj   +1 more source

Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Journal of Experimental & Clinical Cancer Research, 2023
Background Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression.
Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang, Jianing Liu, Wei Zhang, Tao Li, Hanjing Niu, Guochen Bao, Chaojie Wang, Peng George Wang, Jiajia Wang, Xia Li, Taotao Zou, Songqiang Xie   +14 more
doaj   +1 more source

Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment

European Journal of Pharmacology, 2020
Repurposing of approved antiviral drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a promising strategy to treat Coronavirus disease 2019 (COVID-19) patients.

semanticscholar   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Mechanistic insights into post-translational modifications in hepatic fibrosis: pathogenic roles and therapeutic potentials

Journal of Translational Medicine
Hepatic fibrosis, a critical progression in liver disease, has been widely studied. While the activation of stellate cells and the accumulation of extracellular matrix components are recognized as key mechanisms, additional research is necessary to ...
Xiwen Bai, Zhihan Liu, Xianbin Li, Ranran Sun, Zujiang Yu   +4 more
doaj   +1 more source

Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health

Frontiers in Cellular Neuroscience
Due to the increased crewed spaceflights in recent years, it is vital to understand how the space environment affects human health. A lack of gravitational force is known to risk multiple physiological functions of astronauts, particularly damage to the ...
Zihan Li, Jiarui Wu, Tianyuan Zhao, Yiyun Wei, Yajing Xu, Zongjian Liu, Xiaoqiong Li, Xuechai Chen   +7 more
doaj   +1 more source

How to Discover Antiviral Drugs Quickly.

New England Journal of Medicine, 2020
Dynamic Developments in Screening Candidate Drugs Molecular-dynamics simulations together with virtual high-throughput screening provide a means of quick evaluation of existing drugs for antiviral ...
Jerry M. Parks, Jeremy C. Smith
semanticscholar   +1 more source