Results 41 to 50 of about 4,679,298 (290)
International Journal of Quantum Chemistry, 2020 The spread of novel virus SARS‐CoV‐2, well known as COVID‐19 has become a major health issue currently which has turned up to a pandemic worldwide. The treatment recommendations are variable. Lack of appropriate medication has worsened the disease.
S. Kirmani, Parvez Ali, Faizul Azam
semanticscholar +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Antiviral Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus Infection
Frontiers in Microbiology, 2020 Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by SFTS virus (SFTSV), which is a novel bunyavirus.
Mutsuyo Takayama-Ito, M. Saijo
semanticscholar +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Antimicrobial Agents and Chemotherapy, 2020 Drug repositioning is the only feasible option to immediately address the COVID-19 global challenge. We screened a panel of 48 FDA-approved drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which were preselected by an assay of ...
Sangeun Jeon +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Alterations of the oral microbiome in patients reinfected with SARS‐CoV‐2 omicron variants
ViewSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection induces perturbations in the human oral microbiome. However, alterations of the oral microbiome in patients reinfected with SARS‐CoV‐2 omicron variant (ORs) remain uncharacterized. We
Benchen Rao +17 more
doaj +1 more source
MoleculesThe aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral absorption.
Sheng Chang +6 more
doaj +1 more source
Use of antiviral drugs to reduce COVID-19 transmission
Lancet Global Health, 2020 As the coronavirus disease 2019 (COVID-19) spreads, efforts are being made to reduce transmission via standard public health interventions based on isolation of cases and tracing of contacts.
O. Mitjà, B. Clotet
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source