Results 211 to 220 of about 135,285 (241)
Some of the next articles are maybe not open access.
Trends in Pharmacological Sciences, 1989
Recently the first report of zidovudine-resistant human immunodeficiency virus obtained from AIDS patients was published. Resistance to antiviral agents may result from single point mutations in the virus genome. Several mechanisms of resistance have already been elucidated at the biochemical level but the clinical significance of drug resistance is ...
H J, Field, S E, Goldthorpe
openaire +2 more sources
Recently the first report of zidovudine-resistant human immunodeficiency virus obtained from AIDS patients was published. Resistance to antiviral agents may result from single point mutations in the virus genome. Several mechanisms of resistance have already been elucidated at the biochemical level but the clinical significance of drug resistance is ...
H J, Field, S E, Goldthorpe
openaire +2 more sources
Pediatric Clinics of North America, 1995
The ability of viruses to develop resistance to antiviral agents is already a major concern with respect to HIV. This article reviews mechanisms and clinical correlates of antiviral resistance and alternative drugs for treatment of infections due to resistant strains of HIV, herpes simplex virus, cytomegalovirus, varicellazoster virus, and influenza A.
D S, Laufer, S E, Starr
openaire +2 more sources
The ability of viruses to develop resistance to antiviral agents is already a major concern with respect to HIV. This article reviews mechanisms and clinical correlates of antiviral resistance and alternative drugs for treatment of infections due to resistant strains of HIV, herpes simplex virus, cytomegalovirus, varicellazoster virus, and influenza A.
D S, Laufer, S E, Starr
openaire +2 more sources
Nature Microbiology, 2019
Baloxavir marboxil (BXM) represents a promising advance in antiviral chemotherapies for influenza infections. Identification of transmissible BXM-resistant strains in Japan may hit pause on widespread adoption of this therapy and could lead to revision of surveillance practices for emerging viruses.
Karen A. Kormuth, Seema S. Lakdawala
openaire +2 more sources
Baloxavir marboxil (BXM) represents a promising advance in antiviral chemotherapies for influenza infections. Identification of transmissible BXM-resistant strains in Japan may hit pause on widespread adoption of this therapy and could lead to revision of surveillance practices for emerging viruses.
Karen A. Kormuth, Seema S. Lakdawala
openaire +2 more sources
Antiviral Research, 2006
Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
openaire +2 more sources
Almost 30 years ago it was proposed that the selection for antiviral drug resistance should be used as an indicator of antiviral drug activity. In addition to discriminating between cellular toxicity and specific activity directed against a viral target, drug resistant mutants have been used to confirm the mechanism of action of antiviral drugs, to ...
openaire +2 more sources
Drug Resistance in Antiviral Therapy
Clinics in Liver Disease, 2010The introduction of nucleos(t)ide analog therapy has seen the emergence of antiviral drug resistance, which has become the main factor limiting the long-term application of these antiviral agents for patients with chronic hepatitis B. The prevention of resistance requires the adoption of strategies that effectively control virus replication and exploit
Stephen, Locarnini, Scott, Bowden
openaire +2 more sources
Current Opinion in Infectious Diseases, 2014
Current genotypic resistance tests fail to amplify drug-resistant minority variants when they are present below 20% of the total virus population. Next-generation sequencing (NGS) addresses this issue and is being introduced into diagnostic laboratories. This review gives an overview of the resistance tests currently used and explores the opportunities
openaire +2 more sources
Current genotypic resistance tests fail to amplify drug-resistant minority variants when they are present below 20% of the total virus population. Next-generation sequencing (NGS) addresses this issue and is being introduced into diagnostic laboratories. This review gives an overview of the resistance tests currently used and explores the opportunities
openaire +2 more sources
New Antivirals and Antiviral Resistance
2004The field of antiviral therapy is relatively new. Whereas the first antibiotics were available in the 1940s, the first antiviral agent (idoxuridine) was not licensed until the 1960s. Furthermore, the number of antiviral agents available to clinicians today pale in comparison to the number of antibacterial agents.
openaire +2 more sources
Cytomegalovirus (CMV) Resistance to Antivirals
American Journal of Transplantation, 2001This article reviews the biology of cytomegalovirus (CMV), the approved antiviral therapies, and mechanisms of resistance to these drugs. The rates of resistance development in clinical trials are presented, as are the assays for testing susceptibility by phenotypic and genotypic methods.
W L, Drew, C V, Paya, V, Emery
openaire +2 more sources
Annals of the New York Academy of Sciences, 1990
Antiviral drug resistance is an area of increasing importance in acquired immunodeficiency syndrome (AIDS), not only in terms of the human immunodeficiency virus (HIV), but also opportunistic pathogens such as herpes simplex virus (HSV) and human cytomegalovirus (CMV).
openaire +2 more sources
Antiviral drug resistance is an area of increasing importance in acquired immunodeficiency syndrome (AIDS), not only in terms of the human immunodeficiency virus (HIV), but also opportunistic pathogens such as herpes simplex virus (HSV) and human cytomegalovirus (CMV).
openaire +2 more sources
2008
There are two classes of anti-influenza drugs - one class targets the M2 proton channel whereas the other class targets the surface glycoprotein neuraminidase.
Alan J. Hay +2 more
openaire +1 more source
There are two classes of anti-influenza drugs - one class targets the M2 proton channel whereas the other class targets the surface glycoprotein neuraminidase.
Alan J. Hay +2 more
openaire +1 more source