Results 221 to 230 of about 135,285 (241)
Some of the next articles are maybe not open access.
New Antivirals and Drug Resistance
Annual Review of Biochemistry, 2009Progress in the discovery of new antiviral medicines is tempered by the rapidity with which drug-resistant variants emerge. A review of the resistance-suppressing properties of four classes of antivirals is presented: influenza virus neuraminidase inhibitors, HIV protease inhibitors, antibodies, and protein-based fusion inhibitors.
openaire +2 more sources
Hepatitis B antivirals and resistance
Current Opinion in Virology, 2013Antiviral therapy for chronic hepatitis B (CHB) has improved the outcome of patients. However, due to the multiple selection pressures of different nucleos(t)ide analogue, drug resistant HBV variants have emerged. Because of the arrangement of overlapping reading frames in HBV genome, these variants not only have clinical implications such as drug ...
Uma, Devi, Stephen, Locarnini
openaire +2 more sources
Antivirals and resistance: influenza virus
Current Opinion in Virology, 2011Influenza causes annual epidemics of respiratory viral infections are associated with significant morbidity and mortality. Influenza vaccines have been shown to reduce the risk of infection and mitigate against some of the virus' sequellae. Likewise, two classes of antivirals, the adamantanes (amantadine and rimantadine) and the neuraminidase ...
openaire +2 more sources
Modeling Antiviral Resistance in Plants
2012The goal of this chapter is to describe in simple terms how the use of ordinary differential equation (ODE) modeling, in conjunction with experimentation, can be utilized to improve our understanding of the dynamics of gene silencing and virus resistance in plants.
Robert S, Anderssen, Peter M, Waterhouse
openaire +2 more sources
Antiviral resistance and direct-acting antiviral agents for HCV
Antiviral Therapy, 2012Direct-acting antiviral (DAA) agents specifically target viral proteins. Two DAAs have been already been approved for the treatment of HCV infection and many more are in development. DAA treatment of HCV infection, however, leads to the selection of viral variants (produced by the error-prone HCV polymerase) that are resistant to the DAA agent in use ...
Aloia, A., Locarnini, S., Beard, M.
openaire +3 more sources
HIV antiviral drug resistance: patient comprehension
AIDS Care, 2010A patient's understanding and use of healthcare information can affect their decisions regarding treatment. Better patient understanding about HIV resistance may improve adherence to therapy, decrease population viral load and extend the use of first-line HIV therapies.
C Sarai, Racey +9 more
openaire +2 more sources
A perspective on antiviral resistance
Journal of Clinical Virology, 2009More than 25 years after the licensure of aciclovir and then penciclovir, followed by their respective prodrugs valaciclovir and famciclovir, cases of clinically relevant resistance to these drugs in immunocompetent individuals remain very rare. The aim of this review is to focus on the mechanism of action of these anti HSV drugs and then briefly ...
openaire +2 more sources
Resistance of Viruses to Antiviral Drugs
Annual Review of Medicine, 1991In recent years, substantial advances in antiviral therapy have been made; however, in the immunocompromised host, antiviral drug resistance is becoming an issue of increasing clinical importance. Understanding the mechanism of action of antiviral agents, especially those used to treat herpesvirus infections, may enable us to design new therapeutic ...
A G, Freifeld, J M, Ostrove
openaire +2 more sources
Antiviral drug resistance in human cytomegalovirus
Transplant Infectious Disease, 1999Drug‐resistant cytomegalovirus (CMV) should be considered when viral shedding persists after several weeks of therapy. The problem is most likely to arise in the setting of a severely immunosuppressed host with continuing or relapsing disease. Not all treatment failure can be attributed to drug resistance.
openaire +2 more sources
Models of antiviral resistance
Antiviral Research, 1995D W, Kimberlin +4 more
openaire +2 more sources