Results 241 to 250 of about 307,568 (303)

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos   +4 more
wiley   +1 more source

Synthesis and Characterization of Juglone‐Derived cu (II), Mn (II) and Zn (II) Complexes and Investigation of Their Cytotoxic Activities Against Lung and Colon Cancer Cells in Vitro and in Silico

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Three new Zn (II), Cu (II) and Mn (II) complexes have been synthesized from 5‐hydroxy‐1,4‐naphthoquinone (HNQ). Elemental analysis, magnetic susceptibility, UV–Vis, IR and Mass spectrometry have all been used to explore the structural characterization of these compounds.
Mustafa Öztatlıcı   +5 more
wiley   +1 more source

An Evaluation of a Molecular Point‐of‐Care Testing System Designed for Early Diagnosis of Mycoplasma pneumoniae and Respiratory Syncytial Virus Infections

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
On the basis of RT‐qPCR results, 549 oropharyngeal swabs were classified into four groups: MP‐positive (n = 109), MP‐negative (n = 160), RSV‐positive (n = 122), and RSV‐negative (n = 158). Using these as the reference standard, we evaluated a molecular point‐of‐care testing (mPOCT) system (EasyNAT) for simultaneous MP and RSV detection.
Yang Su   +13 more
wiley   +1 more source

Molecular dynamics simulations of oleuropein diffusion in chitosan‐based nanoparticles

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND This study explores the diffusion mechanisms of oleuropein (OLE), a promising polyphenolic compound, within chitosan‐based nanoparticles using molecular dynamics simulations. Chitosan nanoparticles serve as drug delivery carriers, leveraging biocompatibility and tunable release properties influenced by environmental factors such as ...
Bernardino Tirri   +3 more
wiley   +1 more source

Potential of solid‐state microwaves in lab‐scale chemical‐process development

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The integration of a solid‐state microwave (MW) generator into a newly designed, versatile MW reactor ensures improved energy efficiency, precise process control and broader application potential. In its most particular feature, the device supports the modification of dielectric‐radiation orientation and can be operated under ...
Christian Cravotto   +4 more
wiley   +1 more source

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