Results 81 to 90 of about 76,225 (259)

Exploiting the Achilles’ Heel of Viral RNA Processing to Develop Novel Antivirals

Treatment options for viral infections are limited and viruses have proven adept at evolving resistance to many existing therapies, highlighting a significant vulnerability in our defenses.
Peter Stoilov, Mangos, Maria, Choudhary Ahmed, Martha Brown, Leng, Haomin, Chabot, Benoit, Toutant, Johanne, Filomena Grosso, Ahmed, Choudhary, Shkreta, Lulzim, Dahal, Subha, Grosso, Filomena, Johanne Toutant, Alan Cochrane, Cochrane, Alan, Subha Dahal, Haomin Leng, Benoit Chabot, Stoilov, Peter, Huesca, Mario, Ali Zahedi Amiri, Lulzim Shkreta, Mario Huesca, Attisano, Liliana, Zahedi Amiri, Ali, Liliana Attisano, Brown, Martha, Maria Mangos   +27 more
core   +1 more source

Broad-spectrum antivirals targeting viruses from the caliciviridae and hepeviridae [PDF]

, 2019
Human pathogens from the Caliciviridae and Hepeviridae families impose a significant health and economic burden on our global society. Despite the substantial toll caused by viruses such as human norovirus, human sapovirus and hepatitis E virus (HEV), we
Netzler, Natalie
core   +1 more source

Preventing Meningococcal Disease in US Adolescents and Young Adults Through Vaccination

Infectious Diseases and Therapy
In 2022, experts convened under the name Advancing Strategies to Prevent Meningococcal Disease (ARTEMIS) to gather insights on issues related to invasive meningococcal disease (IMD) and meningococcal vaccination in the US. Discussions regarding successes,
Jessica Presa, Ruth Carrico, Jaime E. Fergie, Stephanie Hanenberg, Gary S. Marshall, Kaitlyn Rivard, Jana Shaw, Gregory D. Zimet, Paula Peyrani, Alejandro Cane   +9 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection

Flaviviruses are a diverse group of viruses primarily transmitted through hematophagous insects like mosquitoes and ticks. Significant expansion in the geographic range, prevalence, and vectors of flavivirus over the last 50 years has led to a dramatic ...
Renu Khasa, Tripathi, Aarti, Khasa, Renu, Chauhan, Shailendra, Shailendra Chauhan, Aarti Tripathi   +5 more
core   +1 more source

Transfer of antivirals across the human placenta

, 2005
Background: Viruses cross the placenta and infect the fetus. Antivirals are administered to pregnant women to protect them and the fetus against the viruses.
PACIFICI, GIAN MARIA
core   +1 more source

Incidence of Lyme Borreliosis in Germany: A retrospective observational healthcare claims study

Ticks and Tick-Borne Diseases
Lyme borreliosis (LB) is the most common tick–borne disease in Germany. Although the incidence of LB in Germany has been assessed in several studies, those studies either used data from statutory surveillance, which frequently underreport cases, or data ...
Gordon Brestrich, Christine Hagemann, Joanna Diesing, Nils Kossack, James H. Stark, Andreas Pilz, Frederick J. Angulo, Holly Yu, Jochen Suess   +8 more
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

A Phase 3B, Open-Label Study to Evaluate the Immunogenicity and Safety of the Quadrivalent Meningococcal Nimenrix® Vaccine When Given to Healthy Infants at 3 and 12 Months of Age

Infectious Diseases and Therapy
Introduction Infants and young children typically have the highest age-related risk of invasive meningococcal disease. The immunogenicity and safety of a single primary dose and a booster of a meningococcal A/C/W/Y tetanus toxoid conjugate vaccine ...
Susanna Koski, Federico Martinon-Torres, Mika Rämet, Lefteris Zolotas, Ryan Newton, Roger Maansson, Mark Cutler, Paula Peyrani, Jamie Findlow, Paul Balmer, Luis Jodar, William C. Gruber, Annaliesa S. Anderson, Johannes Beeslaar   +13 more
doaj   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source