Results 61 to 70 of about 81,316 (266)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Racial differences in knowledge, attitudes toward vaccination, and risk practices around Lyme disease in the United States

Frontiers in Public Health
IntroductionLyme disease (LD) incidence in the United States is highly regional, with most cases occurring in 16 high-incidence jurisdictions. LD incidence and severity of disease have been found to vary by race.
Madiha Shafquat, Niyati Patel, Brandon McFadden, Brandon McFadden, James H. Stark, L. Hannah Gould   +5 more
doaj   +1 more source

Antiviral Therapy for the Next Influenza Pandemic

Tropical Medicine and Infectious Disease, 2019
Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic. In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered
Aeron C. Hurt
doaj   +1 more source

Plant-derived antivirals against hepatitis c virus infection [PDF]

, 2018
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide.
Ana Carolina Gomes Jardim, Mark Harris, Harris, Mark, Rahal, P, Rahal, Paula [UNESP], Gomes Jardim, Ana Carolina [UNESP], Paula Rahal, Jacqueline Farinha Shimizu, Shimizu, Jacqueline Farinha [UNESP], Harris, M, Shimizu, JF, Jardim, ACG, Gomes Jardim, Ana Carolina, Rahal, Paula, Shimizu, Jacqueline Farinha   +14 more
core   +1 more source

Anti-Dengue: A Machine Learning-Assisted Prediction of Small Molecule Antivirals against Dengue Virus and Implications in Drug Repurposing

, 2023
Dengue outbreaks persist in global tropical regions, lacking approved antivirals, necessitating critical therapeutic development against the virus.
Manoj Kumar, Akanksha Rajput, Sakshi Gautam, Anamika Thakur   +3 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Antibody persistence and revaccination recommendations of MenACWY-TT: a review of clinical studies assessing antibody persistence up to 10 years after vaccination

Expert Review of Vaccines
Introduction Invasive meningococcal disease (IMD) is potentially fatal and associated with severe sequelae among survivors. It is preventable by several vaccines, including meningococcal vaccines targeting the most common disease-causing serogroups (A, B,
Cynthia Burman, Markus Knuf, Marco Aurelio P. Sáfadi, Jamie Findlow   +3 more
doaj   +1 more source

Antivirals and monoclonal antibody combination therapy in haematological patients in the omicron era [PDF]

: Im We describe here a single-center case series of 27 IC COVID-19 inpatients (mostly with haematological disorders) treated with a combined therapy based on tixagevimab/cilgavimab (T/C) plus small-molecule antivirals (AV), between April 1 2022 and ...
Priscilla Caputi, Daniele Focosi, Fabrizio Maggi, Alessandra D'Abramo, Enrico Girardi, Emanuele Nicastri, Serena Vita, Laura Scorzolini, Emanuela Giombini, Valentina Mazzotta, Alessia Beccacece, Investigation Team Spallanzani COVID-19 case, Cesare Ernesto Maria Gruber, Carmen Pinnetti, Andrea Antinori, Patrizia De Marco, Martina Rueca, Rueca, Martina, Caputi, Priscilla, De Marco, Patrizia, Pinnetti, Carmen, Scorzolini L., Vita, Serena, Mazzotta V., Focosi D., Rueca M., Beccacece, Alessia, Scorzolini, Laura, Maggi, Fabrizio, Mazzotta, Valentina, Maggi F., Nicastri, Emanuele, Gruber, Cesare Ernesto Maria, Focosi, Daniele, Vita S., Antinori, Andrea, Beccacece A., Pinnetti C., Nicastri E., Giombini, Emanuela, Gruber C. E. M., Girardi, Enrico, D'Abramo A., De Marco P., Giombini E., Caputi P., D’Abramo, Alessandra, Girardi E., Antinori A.   +48 more
core   +1 more source

Summary of evidence about treatment with nirmatrelvir-ritonavir versus standard treatment (without antivirals) for COVID-19.

, 2023
Summary of evidence about treatment with nirmatrelvir-ritonavir versus standard treatment (without antivirals) for COVID-19.
Eduardo Henrique Ferreira Bambirra (17138158), Gabriela Carrasco (17138152), Juliana Alvares-Teodoro (9771530), Robin Rojas-Cortés (12019197), Kathiaja Miranda Souza (7367528), José Luis Castro (12019209), Mariana Michel Barbosa (17138155)   +6 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source