Results 51 to 60 of about 81,316 (266)

Global Seroprevalence of Tick-Borne Encephalitis Antibodies in Humans, 1956–2022: A Literature Review and Meta-Analysis

Vaccines
Despite the availability of tick-borne encephalitis (TBE) vaccines, the incidence of TBE is increasing. To understand the historical patterns of infection, we conducted a global meta-analysis of studies before December 2023 reporting human antibody ...
Patrick H. Kelly, Pingping Zhang, Gerhard Dobler, Kate Halsby, Frederick J. Angulo, Andreas Pilz, Harish Madhava, Jennifer C. Moïsi   +7 more
doaj   +1 more source

Investigating Different Mechanisms of Action in Combination Therapy for Influenza

Frontiers in Pharmacology, 2018
Combination therapy for influenza can have several benefits, from reducing the emergence of drug resistant virus strains to decreasing the cost of antivirals. However, there are currently only two classes of antivirals approved for use against influenza,
Kelli Melville, Thalia Rodriguez, Hana M. Dobrovolny   +2 more
doaj   +1 more source

Antivirals for COVID-19: A critical review

, 2020
No specific drugs have been approved for coronavirus disease 2019 (COVID-19) to date as the development of antivirals usually requires time. Therefore, assessment and use of currently available antiviral drugs is critical for a timely response to the ...
Dhama, Kuldeep, Harapan, Harapan, Sharun, Khan, Tiwari, Ruchi, Frediansyah, Andri   +4 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Adult indication 13-valent pneumococcal conjugate vaccine clinical development overview: formulation, safety, immunogenicity (dosing and sequence), coadministration, and efficacy

Expert Review of Vaccines
Introduction There was no 13-valent pneumococcal conjugate vaccine (PCV13) adult antibody concentration threshold regulatory criterion for licensure – unlike the pediatric indication; consequently, for the adult indication, PCV13 serotype-specific ...
Mark A. Fletcher, Beate Schmoele-Thoma, Jelena Vojicic, Derek Daigle, Peter R. Paradiso, Graciela del Carmen Morales   +5 more
doaj   +1 more source

Use of antivirals and antibiotics for vignettes with and without complications.

, 2022
Use of antivirals and antibiotics for vignettes with and without complications.
Jaime Fergie (9726498), James H. Conway (10286773), Manjiri Pawaskar (8718750), Taylor T. Schwartz (12936335), Phani Veeranki (10269737), Joanna MacEwan (8226699), Salome Samant (7462298), Carolyn Harley (6907205), Shikha Surati (12936338)   +8 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Respiratory syncytial virus burden in children under 2 years old in understudied areas worldwide: gap analysis of available evidence, 2012–2022

Frontiers in Pediatrics
BackgroundWe evaluated published evidence (2012–2022) on pediatric RSV burden in 149 countries within World Health Organization (WHO) regions of Africa (AFRO), Americas (AMRO, excluding Canada and the USA), Eastern Mediterranean (EMRO), Europe (EURO ...
Rodrigo Sini de Almeida, João Leite, Jessica E. Atwell, Malak Elsobky, Jorge LaRotta, Mostafa Mousa, Karan Thakkar, Mark A. Fletcher   +7 more
doaj   +1 more source

Availability of oral antivirals against SARS-CoV-2 infection and the requirement for an ethical prescribing approach

, 2022
The first two oral antivirals, molnupiravir and nirmatrelvir-ritonavir, are now becoming available in many countries. These medicines will be indicated to treat mild-to-moderate COVID-19 in non-hospitalised patients who are at high risk of progressing to
Becker, Sören L, Holm, Søren; id_orcid, Dal-Ré, Rafael, Bottieau, Emmanuel, Emmanuel Bottieau, Søren Holm, Sören L Becker, Rafael Dal-Ré   +7 more
core   +1 more source