Results 41 to 50 of about 76,225 (259)

Incidence of symptomatic Borrelia burgdorferi sensu lato infection in Romania, 2018−2023

Parasites & Vectors
Background Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. Although public health surveillance for LB has been conducted in Romania since 2007, the extent of under-detection of ...
Frederick J. Angulo, Julia Olsen, Veronica Purdel, Mihaela Lupșe, Adriana Hristea, Violeta Briciu, Emily Colby, Andreas Pilz, Kate Halsby, Patrick H. Kelly, Gordon Brestrich, Jennifer C. Moïsi, James H. Stark   +12 more
doaj   +1 more source

Incidence of symptomatic Lyme borreliosis in nine European countries

International Journal of Infectious Diseases
Objectives: To better understand the Lyme borreliosis (LB) burden in Europe, we aimed to estimate the incidence of symptomatic Borrelia burgdorferi sensu lato (Bbsl) infections after adjusting public health LB surveillance data for under-detection of ...
Frederick J. Angulo, Emily Colby, Anne-Mette Lebech, Per-Eric Lindgren, Anna Moniuszko-Malinowska, Franc Strle, Julia Olsen, Gordon Brestrich, Andrew Vyse, Madiha Shafquat, L. Hannah Gould, Patrick H. Kelly, Andreas Pilz, Kate Halsby, Jennifer C. Moïsi, James H. Stark   +15 more
doaj   +1 more source

Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds

Molecules, 2021
Plants have had historical significance in medicine since the beginning of civilization. The oldest medical pharmacopeias of the African, Arabian, and Asian countries solely utilize plants and herbs to treat pain, oral diseases, skin diseases, microbial ...
Henry Lowe, Blair Steele, Joseph Bryant, Emadelden Fouad, Ngeh Toyang, Wilfred Ngwa   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness

, 2021
Drug resistance studies on human γ-herpesviruses are hampered by the absence of an in vitro system that allows efficient lytic viral replication. Therefore, we employed murine γ-herpesvirus-68 (MHV-68) that efficiently replicates in vitro as a model to ...
Andrei, Graciela, Temblador, Arturo, Gillemot, Sarah, Trompet, Erika, Snoeck, Robert, Robert Snoeck, Erika Trompet, Topalis, Dimitrios, Sarah Gillemot, Arturo Temblador, Dimitrios Topalis, Graciela Andrei   +11 more
core   +1 more source

Invasive Meningococcal Disease in the Post-COVID World: Patterns of Disease Rebound

Vaccines
Invasive meningococcal disease (IMD) is a global health threat with an unpredictable epidemiology that varies regionally and over time. During the COVID-19 pandemic, the Invasive Respiratory Infection Surveillance Consortium reported widespread ...
Jamie Findlow, Myint Tin Tin Htar, Rodolfo Villena, Paul Balmer   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Antiviral Activity of Zinc Oxide Nanoparticles and Tetrapods Against the Hepatitis E and Hepatitis C Viruses

Frontiers in Microbiology, 2022
Hepatitis E virus (HEV) causes an acute, self-limiting hepatitis. The disease takes a severe form in pregnant women, leading to around 30% mortality. Zinc is an essential micronutrient that plays a crucial role in multiple cellular processes. Our earlier
Jyoti Gupta, Minnah Irfan, Niranjan Ramgir, K. P. Muthe, A. K. Debnath, Shabnam Ansari, Jaya Gandhi, C. T. Ranjith-Kumar, Milan Surjit   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review

Infectious Diseases and Therapy
Invasive meningococcal disease (IMD) is associated with high morbidity and mortality and predominantly caused by five Neisseria meningitidis serogroups (A/B/C/W/Y).
Steven Shen, Jamie Findlow, Paula Peyrani   +2 more
doaj   +1 more source