Results 41 to 50 of about 81,316 (266)

Incidence and risk factors of early HCC occurrence in HCV patients treated with direct acting antivirals: A prospective multicentre study [PDF]

, 2019
An unexpected increased HCC recurrence and occurrence rate among HCV patients treated with direct acting antivirals combination has been reported. Aim of the study was the evaluation of early HCC occurrence rate and its risk factors in a HCV infected ...
Coppola N., Ciardiello F., Berretta M., Fasano M., Rinaldi, Luca, Nevola R., Izzi A., Pafundi P. C., Valente G., Morisco F., Guerrera B., Guarino M., Monari C., Piai G., Martinelli E., Rinaldi L., Perrella A., Miglioresi L., Adinolfi L. E., Sasso F. C., De Luca M., Alessandro Perrella, Massimo De Luca, Antonio Izzi, Barbara Guerrera, Caterina Monari, Maria Guarino, Riccardo Nevola, Pia Clara Pafundi, Lucia Miglioresi, Erika Martinelli, Morena Fasano, Ferdinando Carlo Sasso, Fortunato Ciardiello, Luigi Elio Adinolfi, Luca Rinaldi, Nicola Coppola, Filomena Morisco, Guido Piai, Giovanna Valente, Massimiliano Berretta   +40 more
core   +1 more source

Use of Oral Antivirals Ritonavir-Nirmatrelvir and Molnupiravir in Patients with Multiple Myeloma Is Associated with Low Rates of Severe COVID-19: A Single-Center, Prospective Study

, 2023
In patients with multiple myeloma (MM), SARS-CoV-2 infection has been associated with a severe clinical course and high mortality rates due to the concomitant disease- and treatment-related immunosuppression.
Maria Gavriatopoulou, Magdalini Migkou, Panagiotis Malandrakis, Maria Roussou, Foteini Theodorakakou, Ioannis Ntanasis-Stathopoulos, Efstathios Kastritis, Despina Fotiou, Evangelos Eleutherakis-Papaiakovou, Meletios A. Dimopoulos, Vassiliki Spiliopoulou, Evangelos Terpos, Malandrakis, Panagiotis, Terpos, Evangelos, Eleutherakis-Papaiakovou, Evangelos, Ntanasis-Stathopoulos, Ioannis, Gavriatopoulou, Maria, Fotiou, Despina, Spiliopoulou, Vassiliki, Theodorakakou, Foteini, Migkou, Magdalini, Roussou, Maria, Dimopoulos, Meletios A., Kastritis, Efstathios   +23 more
core   +1 more source

β-Cyclodextrins as affordable antivirals to treat coronavirus infection [PDF]

, 2023
The SARS-CoV-2 pandemic made evident that there are only a few drugs against coronavirus. Here we aimed to identify a cost-effective antiviral with broad spectrum activity and high safety profile.
Roca, Núria, Carla Usai, Pérez, Mónica, Raquel Tenorio, Júlia-Vergara Alert, Gabaldón, José A., Izquierdo Useros, Nuria, Marçal Gallemí, Martin Sachse, Segalés Coma, Joaquim, José P. Cerón-Carrasco, Carrillo, Jorge, Fernández de Castro, Isabel, Dalia Raïch-Regué, Fernández-Sánchez, Sara Y., Blanco, Julià, Cristina Lorca-Oró, Paula Ortega-González, Nuria Izquierdo-Useros, Raïch-Regué, Dàlia, José A. Gabaldón, Vergara-Alert, Júlia, Gallemí, Marçal, Tenorio, Raquel, Gabaldón, José A, Jordana Muñoz-Basagoiti, Sara Y. Fernández-Sánchez, Guillermo Cantero, Perez-Zsolt, Daniel, Josefina Casas, Cristina Risco, Mónica Pérez, Tarrés-Freixas, Ferran, Usai, Carla, Fernández-Oliva, Alberto, Julià Blanco, Lorca-Oró, Cristina, Ferran Tarrés-Freixas, Cantero, Guillermo, Segalés, Joaquim, Alberto Fernández-Oliva, Estrella Nuñez-Delicado, Joaquim Segalés, Núria Roca, Jorge Carrillo, Sachse, Martin, Cerón-Carrasco, José P, Clotet Sala, Bonaventura, Risco, Cristina, Fernández-Sánchez, Sara Y, Daniel Perez-Zsolt, Fernández-Sánchez, Sara Yolanda, Cerón-Carrasco, José P., Isabel Fernández de Castro, Bonaventura Clotet Sala, Muñoz-Basagoiti, Jordana, Alert, Júlia-Vergara, Ortega-González, Paula, Casas, Josefina, Izquierdo-Useros, Núria, Nuñez-Delicado, Estrella   +60 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Real-World Impact of Pneumococcal Conjugate Vaccines on Vaccine Serotypes and Potential Cross-Reacting Non-Vaccine Serotypes

Vaccines
Background: Clinical trials and serological studies have demonstrated that vaccine-induced antibodies can cross-react with some non-vaccine serotypes. However, there are limited longitudinal data on the impact of pneumococcal conjugate vaccines (PCV) on ...
Kevin Apodaca, Lindsay R. Grant, Johnna Perdrizet, Derek Daigle, Gabriel Mircus, Bradford D. Gessner   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Invasive Meningococcal Disease in the Post-COVID World: Patterns of Disease Rebound

Vaccines
Invasive meningococcal disease (IMD) is a global health threat with an unpredictable epidemiology that varies regionally and over time. During the COVID-19 pandemic, the Invasive Respiratory Infection Surveillance Consortium reported widespread ...
Jamie Findlow, Myint Tin Tin Htar, Rodolfo Villena, Paul Balmer   +3 more
doaj   +1 more source

Antiviral Activity of Zinc Oxide Nanoparticles and Tetrapods Against the Hepatitis E and Hepatitis C Viruses

Frontiers in Microbiology, 2022
Hepatitis E virus (HEV) causes an acute, self-limiting hepatitis. The disease takes a severe form in pregnant women, leading to around 30% mortality. Zinc is an essential micronutrient that plays a crucial role in multiple cellular processes. Our earlier
Jyoti Gupta, Minnah Irfan, Niranjan Ramgir, K. P. Muthe, A. K. Debnath, Shabnam Ansari, Jaya Gandhi, C. T. Ranjith-Kumar, Milan Surjit   +8 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review

Infectious Diseases and Therapy
Invasive meningococcal disease (IMD) is associated with high morbidity and mortality and predominantly caused by five Neisseria meningitidis serogroups (A/B/C/W/Y).
Steven Shen, Jamie Findlow, Paula Peyrani   +2 more
doaj   +1 more source