Results 21 to 30 of about 57,674 (258)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Different environmental factors predict the occurrence of tick-borne encephalitis virus (TBEV) and reveal new potential risk areas across Europe via geospatial models

International Journal of Health Geographics
Background Tick-borne encephalitis (TBE) is the most serious tick-borne viral disease in Europe. Identifying TBE risk areas can be difficult due to hyper focal circulation of the TBE virus (TBEV) between mammals and ticks.
Patrick H. Kelly, Rob Kwark, Harrison M. Marick, Julie Davis, James H. Stark, Harish Madhava, Gerhard Dobler, Jennifer C. Moïsi   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Clinical manifestations and outcomes of Tick-borne encephalitis: A systematic literature review

Ticks and Tick-Borne Diseases
Tick-borne encephalitis (TBE) is caused by a viral infection and can lead to acute and persistent damage to the central and peripheral nervous systems.
Kate Halsby, Liesl Gildea, Harish Madhava, Frederick J. Angulo, Andreas Pilz, Wilhelm Erber, Jennifer Moisi, Katharina Schley, Ann Colosia, Johann Sellner   +9 more
doaj   +1 more source

Evaluation of Antibacterial and Antiviral Drug Effectiveness in COVID-19 Therapy: A Data-Driven Retrospective Approach

Pathophysiology, 2022
The clinical manifestations associated with COVID-19 disease is mainly due to a dysregulated host response related to the overexpression of inflammatory markers.
Rika Yulia, Putri Ayu Irma Ikasanti, Fauna Herawati, Ruddy Hartono, Puri Safitri Hanum, Lestiono, Dewi Ramdani, Abdul Kadir Jaelani, Kevin Kantono, Heru Wijono   +9 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Incidence of symptomatic Borrelia burgdorferi sensu lato infection in Romania, 2018−2023

Parasites & Vectors
Background Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), is the most common tick-borne disease in Europe. Although public health surveillance for LB has been conducted in Romania since 2007, the extent of under-detection of ...
Frederick J. Angulo, Julia Olsen, Veronica Purdel, Mihaela Lupșe, Adriana Hristea, Violeta Briciu, Emily Colby, Andreas Pilz, Kate Halsby, Patrick H. Kelly, Gordon Brestrich, Jennifer C. Moïsi, James H. Stark   +12 more
doaj   +1 more source

Incidence of symptomatic Lyme borreliosis in nine European countries

International Journal of Infectious Diseases
Objectives: To better understand the Lyme borreliosis (LB) burden in Europe, we aimed to estimate the incidence of symptomatic Borrelia burgdorferi sensu lato (Bbsl) infections after adjusting public health LB surveillance data for under-detection of ...
Frederick J. Angulo, Emily Colby, Anne-Mette Lebech, Per-Eric Lindgren, Anna Moniuszko-Malinowska, Franc Strle, Julia Olsen, Gordon Brestrich, Andrew Vyse, Madiha Shafquat, L. Hannah Gould, Patrick H. Kelly, Andreas Pilz, Kate Halsby, Jennifer C. Moïsi, James H. Stark   +15 more
doaj   +1 more source

Antiviral Activity of Jamaican Medicinal Plants and Isolated Bioactive Compounds

Molecules, 2021
Plants have had historical significance in medicine since the beginning of civilization. The oldest medical pharmacopeias of the African, Arabian, and Asian countries solely utilize plants and herbs to treat pain, oral diseases, skin diseases, microbial ...
Henry Lowe, Blair Steele, Joseph Bryant, Emadelden Fouad, Ngeh Toyang, Wilfred Ngwa   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source