The BVES Gene Regulates the Homeostasis of Deer Antler Mesenchymal Stem Cells Through Wnt Signaling [PDF]
Biology(1) Background: The proliferation and differentiation of antler mesenchymal stem cells (MSCs) are vital for antler growth. Our group found that BVES is downregulated during peak antler growth but is highly expressed in mesenchymal tissues, suggesting its
Hong Chen +5 more
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Vitamin A Supplementation Induces AMFK Production to Promote Cartilage Proliferation and Antler Growth in Sika Deer [PDF]
AnimalsAntlers are unique mammalian organs that grow rapidly through extensive cartilage proliferation. Vitamin A (VA), via retinoic acid, is known to influence skeletal development, yet its contribution to antler growth remains unclear. We investigated whether
Huazhe Si +15 more
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Local and systemic factors both required for full renewal of deer antlers, and systemic factors only for generic cutaneous regenerative healing [PDF]
Cell RegenerationDeer antlers are the only mammalian organs that periodically regenerate from permanent bony protuberances (pedicles). Antler regeneration relies on the presence of pedicle periosteum (PP) and starts from regenerative healing of wounds created following ...
Wenying Wang, Qianqian Guo, Chunyi Li
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RXFP2-positive mesenchymal stem cells in the antlerogenic periosteum contribute to postnatal development of deer antlers [PDF]
Communications BiologyThe postnatal development of secondary sexual characteristics is a highly complex process governed by diverse molecular signals and serves as a key marker of sexual maturity.
Hengxing Ba +8 more
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Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis [PDF]
Cell Death DiscoveryDiabetes mellitus (DM) exacerbates periodontitis as the high-glucose (HG) environment aggravates local inflammation and periodontal bone resorption. Restoring periodontal homeostasis and promoting periodontal bone repair/regeneration are major challenges
Qianqian Guo +10 more
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Antler casting in relation to parturition in semi-domesticated female reindeer [PDF]
Rangifer, 2013 We investigated the timing of the right and left antler casting in semi-domesticated reindeer (Rangifer tarandus tarandus L.) in relation to parturition using 139 antlered adult individually marked females in 2008-09 between May 5 and June 2; a period ...
Eigil Reimers +2 more
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A vast stem‐progenitor cell pool, richly vascular system, and hybrid ossification drive the daily centimeter‐scale elongation of bony antlers [PDF]
iMetaHengxing Ba +22 more
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Impact of animal source on biocompatibility of bone xenografts: A comparative animal study [PDF]
Journal of Advanced Periodontology and Implant DentistryBackground. The study aimed to compare the results of cytotoxicity and in vivo irritation and sensitization tests of a new antler-derived bone substitute with those of a bovine-derived xenograft. Methods. This study included an in vitro cytotoxicity test
Ardeshir Lafzi +6 more
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A comprehensive assessment of immunomodulatory potentials of Korean antler velvet extract in mouse and neurodegenerative Caenorhabditis elegans models [PDF]
Journal of Animal Science and TechnologyThis study conducts a comprehensive analysis of deer antler velvet’s impact, with a specific emphasis on mouse models and in vitro experiments. The study navigates the intricacies of antler velvet’s variability, encompassing considerations of drying ...
Anna Kang +6 more
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Cell Death Discovery, 2023 Pulmonary fibrosis (PF), a chronic interstitial lung disease, is characterized by over-abundant deposition of extracellular matrix consisting mainly of collagen I.
Guokun Zhang +8 more
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