Results 11 to 20 of about 29,653 (239)

Single-cell transcriptome reveals core cell populations and androgen-RXFP2 axis involved in deer antler full regeneration

Cell Regeneration, 2022
Deer antlers constitute a unique mammalian model for the study of both organ formation in postnatal life and annual full regeneration. Previous studies revealed that these events are achieved through the proliferation and differentiation of antlerogenic ...
Hengxing Ba, Xin Wang, Datao Wang, Jing Ren, Zhen Wang, Hai-Xi Sun, Pengfei Hu, Guokun Zhang, Shengnan Wang, Chao Ma, Yusu Wang, Enpeng Wang, Liang Chen, Tianbin Liu, Ying Gu, Chunyi Li   +15 more
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Antler stem cell-derived exosomes promote regenerative wound healing via fibroblast-to-myofibroblast transition inhibition

Journal of Biological Engineering, 2023
Introduction The typical outcome of mammalian wound healing is scarring, a fibrotic process mediated by myofibroblast aggregation. Perfect healing in a clinical setting is relatively unexplored.
Guokun Zhang, Dongxu Wang, Jing Ren, Jiping Li, Qianqian Guo, Liyan Shi, Chunyi Li   +6 more
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Extracellular vesicles derived from umbilical cord mesenchymal stromal cells alleviate pulmonary fibrosis by means of transforming growth factor-β signaling inhibition

Stem Cell Research & Therapy, 2021
Background Pulmonary fibrosis (PF), the end point of interstitial lung diseases, is characterized by myofibroblast over differentiation and excessive extracellular matrix accumulation, leading to progressive organ dysfunction and usually a terminal ...
Liyan Shi, Jing Ren, Jiping Li, Dongxu Wang, Yusu Wang, Tao Qin, Xiuying Li, Guokun Zhang, Chunyi Li, Yimin Wang   +9 more
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Testing a Local Inbreeding Hypothesis as a Cause of Observed Antler Characteristics in Managed Populations of White-Tailed Deer

Diversity, 2021
The increased use of antler restrictions by state game agencies has led to a focus on antlers by the hunting public, particularly the potential for an association between genetics and antler characteristics. We analyzed microsatellite data from 1231 male
Stephen L. Webb, Randy W. DeYoung, Stephen Demarais, Bronson K. Strickland, Kenneth L. Gee   +4 more
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Study on the Changes in Enzyme and Insulin-like Growth Factor-1 Concentrations in Blood Serum and Growth Characteristics of Velvet Antler during the Antler Growth Period in Sika Deer () [PDF]

Asian-Australasian Journal of Animal Sciences, 2015
This study was conducted to investigate changes in blood enzyme parameters and to evaluate the relationship between insulin-like growth factor-1 (IGF-1), antler growth and body weight during the antler growth of sika deer (Cervus nippon).
Jaehyun Park, Byongtae Jeon, Sungki Kang, Mirae Oh, Myonghwa Kim, Seyoung Jang, Pyojam Park, Sangwoo Kim, Sangho Moon   +8 more
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IGF1R and LOX Modules Are Related to Antler Growth Rate Revealed by Integrated Analyses of Genomics and Transcriptomics

Animals, 2022
Deer antlers are organs of bone and have an extremely rapid growth rate. Thus far, the molecular mechanism underlying rapid antler growth has not been properly elucidated, and key genes driving this growth rate have not been fully identified.
Pengfei Hu, Zhen Wang, Jiping Li, Dongxu Wang, Yusu Wang, Quanmin Zhao, Chunyi Li   +6 more
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Identification and Characterization of Alternative Splicing Variants and Positive Selection Genes Related to Distinct Growth Rates of Antlers Using Comparative Transcriptome Sequencing

Animals, 2022
The molecular mechanism underlying rapid antler growth has not been elucidated. The contrast of the wapiti and sika deer antler provides a potential model for comparative studies for the identification of potent growth factors and unique regulatory ...
Pengfei Hu, Zhen Wang, Jiping Li, Dongxu Wang, Yusu Wang, Quanmin Zhao, Chunyi Li   +6 more
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A Critical Look at the Combined Use of Sulfur and Oxygen Isotopes to Study Microbial Metabolisms in Methane-Rich Environments

Frontiers in Microbiology, 2018
Separating the contributions of anaerobic oxidation of methane and organoclastic sulfate reduction in the overall sedimentary sulfur cycle of marine sediments has benefited from advances in isotope biogeochemistry.
Gilad Antler, Gilad Antler, Gilad Antler, André Pellerin   +3 more
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Velvet Antler Peptides Reduce Scarring via Inhibiting the TGF-β Signaling Pathway During Wound Healing

Frontiers in Medicine, 2022
AimScar formation generally occurs in cutaneous wound healing in mammals, mainly caused by myofibroblast aggregations, and currently with few effective treatment options.
Guokun Zhang, Guokun Zhang, Guokun Zhang, Guokun Zhang, Dongxu Wang, Dongxu Wang, Jing Ren, Jing Ren, Hongmei Sun, Jiping Li, Jiping Li, Shengnan Wang, Shengnan Wang, Liyan Shi, Zhen Wang, Zhen Wang, Mengjie Yao, Haiping Zhao, Chunyi Li, Chunyi Li, Chunyi Li   +20 more
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Comparative antler proteome of sika deer from different developmental stages

Scientific Reports, 2021
Antler is a special bone tissue that has the ability to regenerate completely periodically. It is the fastest growing bone in the animal kingdom. Antler provides a valuable research model for bone growth and mineralization. Antler grows longitudinally by
Ranran Zhang, Yang Li, Xiumei Xing
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