Results 61 to 70 of about 4,641 (279)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Improving Students’ Mastery of English Synonyms and Antonyms Using Bingo and Domino Games (A Classroom Action Research on the Eighth Grade Students of SMP Negeri 3 Maos in the Academic Year 2013/2014)

ELT Forum: Journal of English Language Teaching, 2015
This final project is concerned with the use of bingo and domino games in improving students’ mastery of synonyms and antonyms. The objective of this research is to investigate to what extent bingo and domino games give their influence in teaching ...
Bitha Pracandra Ramadhani Susanto
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The effects of reverse items on psychometric properties and respondents’ scale scores according to different item reversal strategies

International Journal of Assessment Tools in Education
This study aimed to examine the effects of reverse items created with different strategies on psychometric properties and respondents’ scale scores. To this end, three versions of a 10-item scale in the research were developed: 10 positive items were ...
Ömer Ergenekon, Gülşen Taşdelen Teker, Neşe Güler, Mustafa İlhan   +3 more
doaj   +1 more source

ABOUT EQUIVALENCE RELATIONS BETWEEN ‘ANTONYM’ PROVERBS IN CROATIAN AND GERMAN [PDF]

Hum, 2015
The subject of the paper is to determine interlingual equivalency relations between ‘antonym’ proverbs in Croatian and German. We recon on equivalency typology, elaborated by contrastive phraseology and typology of antonyms from the aspect of the ...
Senka Marinčić, Nikolina Pandža
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Synonyms. Antonyms. Homonyms. Lecture 3

Synonyms a) the definition of synonyms; b) classifications of synonyms; c) sources of synonymy; d) criteria of synonymy. 2. Antonyms a) the definition of antonyms; b) classifications of antonyms; c) criteria of antonyms. 3. Homonyms a) the definition of
Skorofatova, Anna
core   +1 more source

Antonyms in dictionary entries : methodological aspects

, 2007
This paper takes the treatment of antonymy in Collins COBUILD Advanced Learner’s English Dictionary (2003) as the point of departure for a discussion about the principles of antonym inclusion in dictionaries and corpus methodologies in lexicology. Ccaled
Paradis, Carita,, Willners, Caroline
core   +6 more sources