Results 91 to 100 of about 1,446 (177)

P6013Evidence for ANTXR2 as a therapeutic target on systemic-to-pulmonary shunt induced pulmonary arterial hypertension

open access: yesEuropean Heart Journal, 2019
Abstract Introduction Pulmonary arterial hypertension secondary to congenital heart disease (CHD-PAH) with systemic-to-pulmonary shunt is characterized by proliferative vascular remodeling. Excessive proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the ...
X Y Liu   +7 more
openaire   +1 more source

Uterine fibrosis in aged nulliparous Antxr2−/− mice is accompanied by atypical vasculature and inflammation.

open access: yes, 2012
(A) CD31 immunostaining (brown color) of three-month-old reproductive tracts reveal atypical/open blood vessels (arrows) throughout the Antxr2−/− uterus and cervix. Boxed areas are blown up to highlight vasculature.
Claire V. Reeves (172057)   +6 more
core   +1 more source

Increased collagen and fibronectin content in aged nulliparous Antxr2−/− uterine tissue.

open access: yes, 2012
(A) Immunofluorescent staining of uterine tissue isolated from six-month-old mice demonstrated increased type I collagen, type IV collagen and fibronectin deposition in the Antxr2−/− tissue. DAPI (blue) was used for nuclear staining.
Claire V. Reeves (172057)   +6 more
core   +1 more source

Original Article Anthrax toxin receptor 2 gene (ANTXR2) rs4333130 is associated with ankylosing spondylitis [PDF]

open access: yes, 2015
: Results of recent published studies on the association between the ANTXR2 rs4333130 polymorphism and the risk of ankylosing spondylitis (AS) have often been conflicting.
Yanjuan Ou
core  

PAD683N and PAD683K Bind and Support Intoxication via ANTXR2

open access: yes, 2013
CHO-R1.1 cells stably expressing human ANTXR2-EGFP (A), human ANTXR1-EGFP (B), and control CHO-R1.1 cells expressing no receptors (C) were analyzed by flow cytometry after incubation with 100 nM purified PA or PAD683K proteins, followed by an anti-PA ...
Darran J Wigelsworth (21911)   +8 more
core   +1 more source

Differential expression of anthrax toxin receptor 2 in cancers of the breast.

open access: yes, 2021
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast ...
Shahan Mamoor
core   +1 more source

Characterizing the Biomechanical and Biochemical Properties of Mouse Uterine Tissue [PDF]

open access: yes, 2022
For a successful pregnancy, the uterus and the cervix work together as a biomechanical structure to protect the fetus until term. During gestation, typically 37 weeks, the uterus undergoes a growth transformation to accommodate the growing fetus and to ...
Yoshida, Kyoko   +2 more
core   +1 more source

Infantile Systemic Hyalinosis: A Case Report with a Novel Mutation

open access: yesOman Medical Journal, 2013
Infantile Systemic Hyalinosis (ISH) (OMIM 236490) is a rare, progressive and fatal autosomal recessive disorder characterized by multiple subcutaneous skin nodules, gingival hypertrophy, osteopenia, joint contractures, failure to thrive, diarrhea with ...
Siham Al Sinani   +2 more
doaj  

ANTXR2 is differentially expressed in glioblastoma.

open access: yes
Glioblastoma is difficult to treat and patients are often provided poor prognosis (1), indicating a requirement for therapeutic target identification and drug development. Differentially expressed genes represent by definition among the most promising targets for the development of novel chemotherapies (2, 3).
openaire   +1 more source

The residues C255/C279 and C230/C315 form two disulfide bonds in the Ig domain of ANTXR2.

open access: yes, 2015
A. In the ANTXR2 ectodomain (residues 38–318), C255/C279 and C230/C315 form two disulfide bonds in the Ig domain (residues 219–318). B. The purified TF-R318 and the C/A mutants of TF-R318 as indicated were run in SDS-PAGE, stained by Coomassie blue.
Jens Puschhof (759973)   +12 more
core   +1 more source

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