Results 241 to 250 of about 12,749 (324)

Identification of a Selective Cell‐Active Inhibitor of Protein Arginine Methyltransferase 5 (PRMT5) for the Treatment of Prostate Cancer by Structure‐Based Virtual Screening

Chemical Biology &Drug Design, Volume 105, Issue 6, June 2025.
Combining previous research, compound SJL2‐1 was identified through virtual screening based on molecular docking. By reducing the expression levels of PRMT5 and AR, it exhibits anti‐proliferative effects, inhibits cell migration and invasion abilities, blocks the cell cycle, and induces apoptosis in AR‐sensitive prostate cancer and CRPC.
TongXiang Diao, Chen Feng, Shuai Liu, Jia‐Li Song, Kong‐kai Zhu, Cheng‐Shi Jiang, Qiang Fu   +6 more
wiley   +1 more source

Impact of SGLT2 inhibitors on survival in gastrointestinal cancer patients undergoing chemotherapy and/or radiotherapy: a real-world data retrospective cohort study. [PDF]

BMC Cancer
Flausino LE, Carrasco AGM, Furuya TK, Tuan WJ, Chammas R.   +4 more
europepmc   +1 more source

PCN286 Descriptive Evaluation of Patient Characteristics and Health Care Resource Utilization of Patients Diagonsed with Ovarian Cancer [PDF]

Greene, M, Greene, N
core   +1 more source

Exposure to androgen deprivation therapy and risk of anastomotic leakage after colorectal cancer surgery

Colorectal Disease, Volume 27, Issue 6, June 2025.
Abstract Aim The risk of anastomotic leakage after colorectal cancer surgery is higher in men, regardless of the anatomical location. Previous studies suggest that this might be due to hormonal differences. The aim of this work was to investigate whether androgen deprivation therapy influenced the incidence of anastomotic leakage.
Martin Rutegård, Isac Norrgård, John Moshtaghi‐Svensson, Jaana Hagström, Ida Hed Myrberg, Anna Lantz, Suvi Rasilainen, Caroline Nordenvall, Malin Sund   +8 more
wiley   +1 more source

High-grade intraepithelial lesions of the anus-patience: A road to wisdom. [PDF]

Colorectal Dis
Gouriou C, Landemaine A, Carlo A, Boisteau E, Henno S, Thibault V, Lievre A, Siproudhis L, Brochard C.   +8 more
europepmc   +1 more source

The Comparison Between Low‐ and High‐Concentration Injection Solution Ability for Colorectal Endoscopic Submucosal Dissection

Journal of Gastroenterology and Hepatology, Volume 40, Issue 6, Page 1419-1427, June 2025.
ABSTRACT Background and Aim Injection solution is important for achieving submucosal elevation in endoscopic submucosal dissection (ESD) and various viscous solutions categorized as low‐concentration injection solution (LCS) or high‐concentration injection solution (HCS) are used.
Naohisa Yoshida, Ryohei Hirose, Yoshikazu Inagaki, Takaaki Murakami, Yutaka Inada, Daisuke Hasegawa, Yuri Tomita, Reo Kobayashi, Osamu Dohi, Ken Inoue, Yoshito Itoh, Naoyuki Yamaguchi   +11 more
wiley   +1 more source

Angioleiomyoma originating from the ano-rectal wall presenting as a perineal mass: a case report. [PDF]

Int J Colorectal Dis
Valiyeva S, Cicerone E, Iacobelli E, Quaglione GR, Pietroletti R.   +4 more
europepmc   +1 more source

Bifidobacterium Lactobacillus Triple Viable Alleviates Slow Transit Constipation by Regulating Gut Microbiota and Metabolism

Journal of Gastroenterology and Hepatology, Volume 40, Issue 6, Page 1561-1573, June 2025.
ABSTRACT Background Gut microbiota plays a crucial role in the pathogenesis and treatment of functional constipation (FC). The aim of this study was to explore the therapeutic effects of Bifidobacterium Lactobacillus triple viable on slow transit constipation (STC).
Mei Luo, Peiwei Xie, Xuehong Deng, Jiahui Fan, Lishou Xiong   +4 more
wiley   +1 more source

Pigmented basal cell carcinoma of the anus: a rare entity with diagnostic challenges. [PDF]

J Surg Case Rep
Fuentes-Calvo KJ, Silva-Ramos CS, Arechavala-López SF, Aguilar-Ruiz F, Arias-Ruiz LF, Trejo-Ávila M.   +5 more
europepmc   +1 more source

Antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID)

Veterinary Dermatology, Volume 36, Issue 3, Page 234-282, June 2025.
Background – Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives – To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler, Christine L. Cain, Lluís Ferrer, Koji Nishifuji, Katarina Varjonen, Mark G. Papich, Luca Guardabassi, Siân M. Frosini, Emi N. Barker, J. Scott Weese   +9 more
wiley   +1 more source