Results 221 to 230 of about 18,068 (256)

Biological and In Silico Evaluation of Novel Methoxyphenol–1,2,3‐Triazole Hybrids as Multifunctional Anti‐Alzheimer's and Anticancer Agents

open access: yesChemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Novel methoxyphenol‐1,2,3‐triazole hybrids were synthesized as multifunctional leads. Compound 5e exhibited potent PC3 cytotoxicity (IC50: 3.57 μM), while 5c showed superior AChE inhibition (IC50: 1.44 μM) and high selectivity (SI: 6.22). DFT and docking studies confirmed their dual‐targeting potential, providing a robust scaffold for Alzheimer's and ...
Sultan Onur   +2 more
wiley   +1 more source

A Multicenter Prospective Study on the Safety and Efficacy of the New Low Axial Force Self‐Expandable Metallic Stent With Slim Delivery System for Malignant Colorectal Obstruction

open access: yesDigestive Endoscopy, Volume 38, Issue 6, June 2026.
This new low‐AF stent with 9Fr delivery system is highly safe and effective, demonstrating high technical and clinical success rates for placement and a low incidence of adverse events. ABSTRACT Objectives Self‐expandable metallic stents are widely used for malignant colorectal obstruction, and low axial force (AF) stents have been developed to reduce ...
Takeshi Mizumoto   +13 more
wiley   +1 more source

Primary Extragastrointestinal Stromal Tumor of the Dorsolateral Anorectum Resected via a Posterior Approach: A Case Report. [PDF]

open access: yesSurg Case Rep
Hasegawa M   +12 more
europepmc   +1 more source

How to Define the Gastroesophageal Junction

open access: yesDigestive Endoscopy, Volume 38, Issue 6, June 2026.
ABSTRACT Adenocarcinomas at the gastroesophageal junction (GEJ) are increasingly common worldwide. Current classifications, such as Siewert type II and Nishi, provide a foundation, but establishing a transparent and widely accepted framework could considerably enhance identification and treatment efforts.
Ken‐ichi Mukaisho   +6 more
wiley   +1 more source

Fournier's gangrene with anal cancer: a case report and literature review. [PDF]

open access: yesJ Surg Case Rep
Lee Y   +6 more
europepmc   +1 more source

Anal neoplasm in colonoscopy: What endoscopists need to know. [PDF]

open access: yesWorld J Gastrointest Endosc
Gomes A   +8 more
europepmc   +1 more source

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