Results 121 to 130 of about 1,107,104 (361)
A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Advanced Science, EarlyView.Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria +5 more
wiley +1 more source
Translational PsychiatryExposure to traumatic life events may compromise physical and mental health of specific subjects. While some individuals extinguish fear appropriately, others exhibit an inefficient and persistent fear response, with remarkable differences between sexes.
Marc Ten-Blanco +7 more
doaj +1 more source
Psychological Test Adaptation and Development: Introduction: The Lehrer–Woolfolk Anxiety Symptom Questionnaire (LWASQ) is a self-report questionnaire based on the tripartite model of Lang (1971) for measuring treatment progress. However, so far little is known about its psychometric qualities.
Vivian Peerbooms +4 more
doaj +1 more source
Advanced Science, EarlyView.This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song +15 more
wiley +1 more source
Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling
Advanced Science, EarlyView.The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen +13 more
wiley +1 more source
Effect of sleep quality on repetitive transcranial magnetic stimulation outcomes in depression
Frontiers in PsychiatryIntroductionWhile repetitive transcranial magnetic stimulation (rTMS) is effective for 50-60% of those treatment-resistant depression, it is critical to identify predictors of response for optimal patient selection to improve therapy. Insomnia is a known
Jamie Kweon +8 more
doaj +1 more source
Fear and fitness: An evolutionary analysis of anxiety disorders [PDF]
, 1994 Isaac Marks, Randolph M. Nesse
openalex +1 more source
DeckerMed Transitional Year Weekly Curriculum™, 2017 Anxiety disorders are the most common psychiatric disorders among adults in the United States. Although anxiety disorders generally result in significant psychosocial impairment, most adults do not seek treatment until many years after the onset of the anxiety disorder.
openaire +1 more source
An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance
Advanced Science, EarlyView.This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue +9 more
wiley +1 more source
Adrenergic status in anxiety disorders: Platelet alpha2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorders patients and in normal subjects [PDF]
, 1990 Oliver G. Cameron +5 more
openalex +1 more source