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Anxiolytic-Like Effect of Baicalin and its Additivity with other Anxiolytics [PDF]
Planta Medica, 2006 Baicalin, a naturally occurring flavonoid, was previously reported to exert anxiolytic-like effects in the Vogel conflict test. In the present study, the anxiolytic effects of baicalin alone and in combination with other anxiolytics were tested in mice using the elevated plus-maze (EPM).
Xu, Zhiwen +7 more
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Pharmacogenetics of anxiolytic drugs
Journal of Neural Transmission, 2009Acute and chronic anxiety represents the core symptoms in anxiety disorders. Anxiolytic pharmacological treatment mainly consists in administration of benzodiazepines and antidepressants. Whereas benzodiazepines show little, antidepressants show a relative large interindividual variability in terms of drug response where about one-third of patients do ...
Renan P. Souza +3 more
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Mental Retardation and Developmental Disabilities Research Reviews, 1999
The nature of anxiety and its biological basis is reviewed, as are the causes and types of pathological anxiety and their pharmacological treatment. The main drugs used in the treatment of anxiety work by depressing the brain and hence perception and response to stressors.
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The nature of anxiety and its biological basis is reviewed, as are the causes and types of pathological anxiety and their pharmacological treatment. The main drugs used in the treatment of anxiety work by depressing the brain and hence perception and response to stressors.
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2006
Publisher Summary Drugs used for relieving anxiety, stress, worry, and fear that do not detract attention from or affect psychomotor activity of the patient are called anxiolytics or tranquilizers. Most of them have sedative and hypnotic action, and in high doses their effects are in many ways similar to barbiturate action.
Ruben Vardanyan, Victor J. Hruby
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Publisher Summary Drugs used for relieving anxiety, stress, worry, and fear that do not detract attention from or affect psychomotor activity of the patient are called anxiolytics or tranquilizers. Most of them have sedative and hypnotic action, and in high doses their effects are in many ways similar to barbiturate action.
Ruben Vardanyan, Victor J. Hruby
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Pharmacology Biochemistry and Behavior
Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABAA-receptor (GABAAR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and ...
Rok, Cerne +3 more
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Anxiety disorders are the most prevalent psychiatric pathology with substantial cost to society, but the existing treatments are often inadequate. This has rekindled the interest in the GABAA-receptor (GABAAR) positive allosteric modulator (PAM) compounds, which have a long history in treatment of anxiety beginning with diazepam, chlordiazepoxide, and ...
Rok, Cerne +3 more
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2016
This chapter will present clinical evidence for the efficacy of herbal treatments which address symptoms of anxiety primarily via their effects on cognitive functioning. Brahmi (Bacopa monnieri) Ginkgo (Ginkgo Biloba) Lemon Balm (Melissa officinalis) Tea (Camellia sinensis) Sage (Salvia spp.) Rosemary (Rosmarinus officinalis)
Steiner, Genevieve Z. (R18023) +1 more
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This chapter will present clinical evidence for the efficacy of herbal treatments which address symptoms of anxiety primarily via their effects on cognitive functioning. Brahmi (Bacopa monnieri) Ginkgo (Ginkgo Biloba) Lemon Balm (Melissa officinalis) Tea (Camellia sinensis) Sage (Salvia spp.) Rosemary (Rosmarinus officinalis)
Steiner, Genevieve Z. (R18023) +1 more
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Anxiolytics, sedatives and hypnotics
Anaesthesia & Intensive Care Medicine, 2007Anxiolytics and sedatives are used in current anaesthetic practice for anxiolysis before surgery and as adjuvants during anaesthesia. The safety profile of these agents depends on their pharmacokinetic and pharmacodynamic profiles, patient comorbidity and the experience of the clinician.
Anthony Absalom, Caroline Meerts
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Anxiolytic effects of benzalphthalides
Bioorganic & Medicinal Chemistry Letters, 2005Anxiolytic effects induced by benzalphthalides on mice have been evaluated. The evaluation was based on the spent time and the number of entries of animals into the open arms in the elevated plus maze test. Single administration of benzalphthalides 1 and 11 induced significant increments in both parameters, thus revealing their potentiality as new ...
Maribel Herrera-Ruiz +5 more
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Anaesthesia & Intensive Care Medicine, 2004
Abstract Drugs such as the barbiturates and the benzodiazepine have anxiolytic and hypnotic activity and both act by enhancing the action of γ-aminobutyric acid (GABA) via an action at separate binding sites of the GABA A receptor. While anxiolytic activity was not a particular disadvantage when these drugs were used as hypnotics, hypnosis was a ...
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Abstract Drugs such as the barbiturates and the benzodiazepine have anxiolytic and hypnotic activity and both act by enhancing the action of γ-aminobutyric acid (GABA) via an action at separate binding sites of the GABA A receptor. While anxiolytic activity was not a particular disadvantage when these drugs were used as hypnotics, hypnosis was a ...
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Neuropharmacology of Sedatives and Anxiolytics
2015Sedative drugs are intended to cause various degrees of drowsiness. Animal experiments indicate that barbiturates induce these effects primarily by depression of the reticular activating system in the rostral brainstem. This in turn potentiates the thalamic recruiting system, thereby inducing 'barbiturate bursts' in the EEG.
William Schallek, Walter Schlosser
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