Results 221 to 230 of about 23,910 (287)

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju, HeeJae Choi, Shilpa Madari, Annie Carlisle, Ashish Sharma, Christina Kunz, Fenglei Huang   +6 more
wiley   +1 more source

Estrogen/Esr2b signaling‐dependent, female‐biased expression of a neuropeptide Y gene in the medaka brain

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract A recent study showed that female medaka lacking the estrogen receptor gene esr2b are unreceptive to male courtship and instead court other females. In this study, we investigated the brain transcriptome of esr2b‐deficient females to explore the underlying mechanisms of this behavioral phenotype, and identified npyb, one of the two ...
Yuki Homan, Yuji Nishiike, Mika Sato‐Tsukamoto, Daisuke Saito, Mikita Suyama, Yasuyuki Ohkawa, Fumiya Takahashi, Takashi Baba, Ken‐ichirou Morohashi, Kataaki Okubo   +9 more
wiley   +1 more source

Phenotypic Variability in Slow‐Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Slow‐wave sleep (SWS; stage N3) is often reported as reduced in depression, yet variability across depressive phenotypes remains poorly characterised. This study aimed to determine whether N3 architecture—proportion, duration, and latency—identifies clinically distinct profiles in major depressive episode (MDE).
Antoine Salmeron, Pierre A. Geoffroy, Lily Vissouze, Jeanne Leseur, Heloise Rach, Michel Lejoyeux, Justine Frija, Marie Pia d’Ortho, Julia Maruani   +8 more
wiley   +1 more source

Prescription of Psychotropic Drugs for Chronic Insomnia in Primary Care

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Insomnia is the most prevalent sleep disorder in adults, representing a major public health problem. Healthcare management in a specific area first requires analysing its current practices and issues. We conducted a retrospective observational study of over 100,000 patients from two large primary care databases in the public healthcare ...
Jesús Escribá‐Alepuz, Lidia Herrero‐Huertas, María García‐Gil, Estefanía Estévez‐López, Francisco Javier Puertas, Manuel de Entrambasaguas   +5 more
wiley   +1 more source

Comments on "Association Between Self-Reported Psychiatric Diseases and Oral Health Among Older Adults". [PDF]

Spec Care Dentist
Dash P.
europepmc   +1 more source

Mortality risk associated with psychotropic medications frequently substituted for antipsychotics to manage behaviours that challenge in people with dementia: a systematic review

Shepherd G, Lau Y, Cooper C, Petersen I, Bazo-Alvarez JC, Banerjee S, Knapp M, Davies N, Smith HC, Muralidhar M, Sijtsma E, Stone P, Yilmaz M, Arrojo F, Ward J, Reddall C, Ogden M, Dowridge W, Demntiz-King H.   +18 more
europepmc   +1 more source

Sertraline safety in adolescents experiencing a depressive episode during first 3 weeks: added anxiolytic matters more than CYP2C19 polymorphisms. [PDF]

Front Pharmacol
Ivashchenko DV, Sobur VV, Grass SV, Basova AY, Kondratieva RV, Shagovenko EN, Chernetsova YV, Tuchkova SN, Korsakov IN, Markov SI, Mirzaev KB, Shevchenko YS, Sychev D.   +12 more
europepmc   +1 more source

Analysis of Psychotropic Polypharmacy and Associated Factors in Antidepressant-Treated Patients With Depressive Disorder: A Population-Based Cohort Study Using Real World Data. [PDF]

Depress Anxiety
Infante-Ventura D, Rodríguez-Díaz B, García-Bello MÁ, Válcarcel-Nazco C, Estupiñán-Romero F, Acosta Artiles FJ, González de León B, Hurtado-Navarro I, Del Pino-Sedeño T.   +8 more
europepmc   +1 more source