Results 71 to 80 of about 20,895 (217)

FDX1 Depletion Activates CD8+ T Cell Antitumor Immunity by Promoting DMBT1 Secretion in Cuproptosis of Colorectal Cancer

Cancer Science, EarlyView.
Elesclomol‐induced cuproptosis potently activates both innate and adaptive antitumor immunity, especially CD8+ T cell immunity. FDX1 serves as a central regulator of CD8+ T cell functionality through DMBT1 downregulation during cuproptosis in colorectal cancer.
Jieqiong Wu, Zaixi Lian, Mingzhou Li, Xingtu Qin, Xiaoyu Lei, Lihua Yang, Lin Bing, Qiuyue Li, Lingyan Zhou, Zhiyang Ma, Xuemei Xu, Jinghao Huang, Zilong Chen, Lijie Chen, Lingjie Zhang, Zhiyuan Xiao, Xiangyu Jian, Xiaoqin Zhang, Yanqing Ding, Yaping Ye, Li Liang, Hongli Jiao, Shuyang Wang   +22 more
wiley   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

Cell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu, Zihan Cai, Hualing Sun, Haikun Yu, Bicheng Zhang, Chi Zhang, Yi Fan, Xiaoxuan Zhu, Yueqi Ni, Yu Cui, Kaixin Wang, Zhe Li, Xinyi Zhou, Qing He, Yanru Wu, Yufeng Zhang   +15 more
wiley   +1 more source

Serum Levels of IL-6, IL-10, TNF-α, and Vitamin D: Their Correlation with Acute Otitis Media in Short-Stature Pediatric Patients

Journal of Inflammation Research
Arif Dermawan,1 Bejo Ropii,2 Lina Lasminingrum,1 Wijana Hasansulama,1 Budi Setiabudiawan3,4 1Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine Universitas Padjadjaran/Dr.
Dermawan A, Ropii B, Lasminingrum L, Hasansulama W, Setiabudiawan B   +4 more
doaj  

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Study to assess incidence of acute otitis media in children under 5 years of age in Russia (PAPIRUS-AOM) [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2017
At this prospective 12-months study we investigated the incidence of acute otitis media (AOM), it's severity and frequency of hospitalization in children from 0 to 5 years old.
Kozlov R.S., Muravyev A.A., Scherbakov M.E., Rodnikova V.Y., Romanenko V.V., Safianov K.N., «PAPIRUS» Study Group   +6 more
doaj  

Patterns of anti-osteoporosis medication use among women at high risk of fracture: findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW).

PLoS ONE, 2013
ObjectiveTo assess patterns of anti-osteoporosis medication (AOM) use over 3 years among women at high risk of major fracture.MethodsThe GLOW registry follows a cohort of more than 40,000 women aged ≥ 55 from 615 primary care practices in 10 countries ...
Stephen Gehlbach, Frederick H Hooven, Allison Wyman, Adolfo Diez-Perez, Jonathan D Adachi, Xuemei Luo, Andrew G Bushmakin, Frederick A Anderson, GLOW Investigators   +8 more
doaj   +1 more source

Endocervical gastric‐type AIS: a rare histologic finding that further supports the hypothesis of a pyloric‐type metaplastic origin

Histopathology, EarlyView.
Background Gastric‐type adenocarcinoma in situ (gAIS) is a rare, HPV‐independent precursor of cervical adenocarcinoma with incompletely defined histogenesis. Aims To report a case of gAIS and its association with pyloric‐type gastric metaplasia. Materials and Methods A case of gAIS in a 70‐year‐old woman with atypical glandular cells (Pap test) and ...
Michele Paudice, Veronica Parrella, Giulia Scaglione   +2 more
wiley   +1 more source

Rethinking informal circularity through metanarratives: Tensions, insights and directions for management research

International Journal of Management Reviews, EarlyView.
Abstract This study explores the intersection of the informal and circular economies and its implications for business, management and organization (BMO) scholarship and practice. Informal circularity, practices of collecting, reusing, repairing, recycling and repurposing materials outside formal economic, legal and regulatory arrangements, constitutes
Tulin Dzhengiz, Ling Li, Vildan Tasli Karabulut, Maryline Kiptoo   +3 more
wiley   +1 more source

Managing parallel business models in the circular transition: From tension recognition to synergy realization

International Journal of Management Reviews, EarlyView.
Abstract Organizations are increasingly urged to adopt circular economy principles for their business strategies, yet ‘going circular’ is challenging. The circular business model (CBM) transition—shifting from linear to CBMs—is complex, and our initial analysis of the literature indicated that organizations do not know how to implement circular ...
Farshad Hajiakbari, Alex A. Alblas, Néomie Raassens, Marcel L. A. M. Bogers   +3 more
wiley   +1 more source

The effects of diallyl disulfide on certain oxidative stress and biochemical parameters in an azoxymethane-induced colon cancer model [PDF]

Eurasian Journal of Veterinary Sciences
The aim of the present study is to investigate the effects of diallyl disulfide (DADS), an active compound of garlic, on certain serum biochemical and oxidative stress parameters in colon cancer induced by azoxymethane (AOM) in rats.
Buse Turan, Seyfullah Haliloglu, Zafer Bulut   +2 more
doaj