Results 141 to 150 of about 3,137 (211)

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Myocardial stretch‐induced ROS production is enhanced prior to the development of heart failure under TAC‐induced pressure overload

The Journal of Physiology, EarlyView.
Abstract figure legend To elucidate the relationship between oxidative stress in heart failure induced by chronic mechanical overload and physiological NOX2‐derived stretch‐induced reactive oxygen species (ROS) that support myocardial contractility during acute stretch, we investigated the changes in stretch‐induced ROS following transverse aortic ...
Yumiko Chiba, Keiko Kaihara, Hiroki Tanaka, Naoki Nakagawa, Gentaro Iribe   +4 more
wiley   +1 more source

CO2 chemoreflex contributions to ventilatory long‐term facilitation

The Journal of Physiology, EarlyView.
Abstract figure legend To determine whether changes in CO2 chemoreflex sensitivity contribute to ventilatory long‐term facilitation (LTF), we tested the hypothesis that hypercapnic acute intermittent hypoxia (AIH) induces ventilatory LTF and enhances peripheral, but not central, chemoreceptor CO2 chemoreflex sensitivity.
Susan V. Cross, Elizabeth Keen, Tom E. Nightingale, Zubair Ahmed, George M. Balanos, Joseph F. Welch   +5 more
wiley   +1 more source

Knockdown of mitotically associated long non‐coding RNA dysregulates endothelial functions, transcriptome and proteome

The Journal of Physiology, EarlyView.
Abstract figure legend Downregulation of mitotically associated long non‐coding RNA (MANCR) disturbs transcriptome and proteome in endothelial cells, possibly leading to endothelial and vascular dysfunction in preeclampsia. Abstract Preeclampsia (PE) is a hypertensive disorder during pregnancy, which is characterized by a wide spectrum of endothelial ...
Si‐Yan Zhang, Chi Zhou, Jing Zheng
wiley   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, Volume 30, Issue 6, Page 908-924, December 2026.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, Volume 309, Issue 12, Page 3660-3668, December 2026.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source

An Anatomist's View on the Crosstalk Between the Liver and the Lung

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
The liver and the lung have a similar three‐dimensional and cellular architecture as well as functional communalities. The structural, functional, and pathophysiological interplay between both organs suggests the existence of an interorgan axis, the liver‐lung axis. Created in biorender.com.
Tanja Kloock, Julia Schipke, Christian Mühlfeld   +2 more
wiley   +1 more source